1315378-69-8
Chemical Structure
Pep2-AVKI
- CAS No.: 1315378-69-8
- Formula:C60H93N13O17
- Molecular Weight:1268.46
IUPAC Name: (2S,5S,8S,11S,14S)-14-((2S,8S,11S,14S,17S)-17-amino-14-(2-amino-2-oxoethyl)-2-((S)-sec-butyl)-8-(4-hydroxybenzyl)-18-(4-hydroxyphenyl)-11-isopropyl-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaoctadecanamido)-5-(4-aminobutyl)-2-((S)-sec-butyl)-8-isopropyl-11-methyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazaheptadecanedioic acid
InChIKey: SODUKHPKIVEQLX-OCXIBOJYSA-N
SMILES: OC(C=C1)=CC=C1C[C@@H](C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@H](C(O)=O)[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)NC([C@H](C(C)C)NC([C@H](CC(N)=O)NC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)=O
Biological Activity: Pep2-AVKI is a selective peptide inhibitor of the binding of the AMPA receptor subunit (GluR2) at the C-terminal PDZ site to C-kinase (PICK1). Pep2-AVKI does not affect the binding of (AMPA-type glutamate receptor) GluA2 to GRIP or ABP. Pep2-AVKI does not increase the amplitude of AMPA currents. pep2-AVKI can be used to study neurological diseases[1][2][3][4].
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Pep2-AVKI | Pep2-AVKI is a selective peptide inhibitor of the binding of the AMPA receptor subunit (GluR2) at the C-terminal PDZ site to C-kinase (PICK1). Pep2-AVKI does not affect the binding of (AMPA-type glutamate receptor) GluA2 to GRIP or ABP. Pep2-AVKI does not increase the amplitude of AMPA currents. pep2-AVKI can be used to study neurological diseases. | |||||||||||||||||||||
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- [1]. Liu SJ, et al. Subunit interaction with PICK and GRIP controls Ca2+ permeability of AMPARs at cerebellar synapses. Nat Neurosci. 2005 Jun;8(6):768-75. [Content Brief]
- [2]. Pittaluga A, et al. Trafficking of presynaptic AMPA receptors mediating neurotransmitter release: neuronal selectivity and relationships with sensitivity to cyclothiazide. Neuropharmacology. 2006 Mar;50(3):286-96. [Content Brief]
- [3]. Summa M, et al.Hippocampal AMPA autoreceptors positively coupled to NMDA autoreceptors traffic in a constitutive manner and undergo adaptative changes following enriched environment training. Neuropharmacology. 2011 Dec;61(8):1282-90. [Content Brief]
- [4]. Toyoda H, et al. Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex. J Cell Physiol. 2007 May;211(2):336-43. [Content Brief]
Keywords
