Pep2-AVKI
Pep2-AVKI is a selective peptide inhibitor of the binding of the AMPA receptor subunit (GluR2) at the C-terminal PDZ site to C-kinase (PICK1). Pep2-AVKI does not affect the binding of (AMPA-type glutamate receptor) GluA2 to GRIP or ABP. Pep2-AVKI does not increase the amplitude of AMPA currents. pep2-AVKI can be used to study neurological diseases.
For research use only. We do not sell to patients.
- CAS No.: 1315378-69-8
- Formula: C60H93N13O17
- Molecular Weight:1268.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Pep2-AVKI (1 mM) selectively binds to PICK and does not alter (Miniature Excitatory Postsynaptic Current) mEPSC amplitude or frequency, but inhibits the activity-induced increase in (Excitatory Postsynaptic Current) EPSC amplitude ratio in cerebellar stellate cells[1].
Pep2-AVKI (1 mM) blocks the increase in synaptic GluR2-containing receptors in cerebellar stellate cells[1].
Pep2-AVKI increases AMPA-evoked (radiolabeled norepinephrine) [3H]NA and (radiolabeled D-aspartate) [3H]D-ASP and increases 10 μM NMDA/1 μM Glycine (HY-Y0966)/50 μM (S) AMPA-induced tritium release, but does not alter 10 μM NMDA/1 μM Glycine-induced [3H]D-ASP release in hippocampal synaptosomes[2][3].
Pep2-AVKI (100 μM) blocks (Long-Term Depression) LTD in postsynaptic neurons[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1315378-69-8
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Molecular Weight 1268.46
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Formula C60H93N13O17
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Sequence
Tyr-Asn-Val-Tyr-Gly-Ile-Glu-Ala-Val-Lys-Ile
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Sequence Shortening
YNVYGIEAVKI
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Liu SJ, et al. Subunit interaction with PICK and GRIP controls Ca2+ permeability of AMPARs at cerebellar synapses. Nat Neurosci. 2005 Jun;8(6):768-75. [Content Brief]
[2]. Pittaluga A, et al. Trafficking of presynaptic AMPA receptors mediating neurotransmitter release: neuronal selectivity and relationships with sensitivity to cyclothiazide. Neuropharmacology. 2006 Mar;50(3):286-96. [Content Brief]
[3]. Summa M, et al.Hippocampal AMPA autoreceptors positively coupled to NMDA autoreceptors traffic in a constitutive manner and undergo adaptative changes following enriched environment training. Neuropharmacology. 2011 Dec;61(8):1282-90. [Content Brief]
[4]. Toyoda H, et al. Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex. J Cell Physiol. 2007 May;211(2):336-43. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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