1449765-65-4
1449765-65-4
Chemical Structure
SLR080811
- CAS No.: 1449765-65-4
- Formula:C21H31N5O
- Molecular Weight:369.50
IUPAC Name: (R)-2-(3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide
InChIKey: JUZGDDYZTNXXNG-GOSISDBHSA-N
SMILES: N=C(N1[C@@H](C2=NC(C3=CC=C(C=C3)CCCCCCCC)=NO2)CCC1)N
Biological Activity: SLR080811 is a guanidine-based selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 1.3 μM, exhibiting ~10-fold selectivity over SphK1 (Ki = 12 μM). SLR080811 reduces sphingosine 1-phosphate (S1P) levels in vitro, but drives a SphK1-dependent increase in S1P in mice. SLR080811 can be used for cancers and fibrosis research[1].
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SLR080811 | SLR080811 is a guanidine-based selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 1.3 μM, exhibiting ~10-fold selectivity over SphK1 (Ki = 12 μM). SLR080811 reduces sphingosine 1-phosphate (S1P) levels in vitro, but drives a SphK1-dependent increase in S1P in mice. SLR080811 can be used for cancers and fibrosis research. | |||||||||||||||||||||
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