156547-56-7
Chemical Structure
FSCPX
- CAS No.: 156547-56-7
- Formula:C23H27FN4O6S
- Molecular Weight:506.55
IUPAC Name: 3-(8-cyclopentyl-2,6-dioxo-1-propyl-1,2,6,9-tetrahydro-3H-purin-3-yl)propyl 4-(fluorosulfonyl)benzoate
InChIKey: XJLGXHIRSHTRPQ-UHFFFAOYSA-N
SMILES: O=C(OCCCN(C(N1CCC)=O)C2=C(N=C(C3CCCC3)N2)C1=O)C4=CC=C(S(=O)(F)=O)C=C4
Biological Activity: FSCPX is a potent and selective irreversible antagonist of A1 adenosine receptor (A1AR), with low nanomolar potency for binding to the A1AR. FSCPX could modify the effect of NBTI, a nucleoside transport inhibitor, by reducing the interstitial adenosine level in the guinea pig atrium[1][2].
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FSCPX | 99.72% | FSCPX is a potent and selective irreversible antagonist of A1 adenosine receptor (A1AR), with low nanomolar potency for binding to the A1AR. FSCPX could modify the effect of NBTI, a nucleoside transport inhibitor, by reducing the interstitial adenosine level in the guinea pig atrium. | ||||||||||||||||||||
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- [1]. Beauglehole AR, et, al. New irreversible adenosine A(1) antagonists based on FSCPX. Bioorg Med Chem Lett. 2002 Nov 4; 12(21): 3179-82. [Content Brief]
- [2]. Erdei T, et, al. FSCPX, a Chemical Widely Used as an Irreversible A₁ Adenosine Receptor Antagonist, Modifies the Effect of NBTI, a Nucleoside Transport Inhibitor, by Reducing the Interstitial Adenosine Level in the Guinea Pig Atrium. Molecules. 2018 Aug 3 [Content Brief]
Keywords
