1638811-35-4
Chemical Structure
Dedimethyl MitoCur-1
- CAS No.: 1638811-35-4
- Formula:C63H60Cl2O6P2
- Molecular Weight:1046.00
InChIKey: AQAGPINGQUSILN-HDYZHHDRSA-L
SMILES: COC(C=C(C=C1)/C=C/C(CC(/C=C/C2=CC(OC)=C(C=C2)OCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O)=O)=C1OCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8.[Cl-].[Cl-]
Biological Activity: Dedimethyl MitoCur-1 is a mitochondria-targeted curcuminoid derived from MitoCur-1 (HY-150228) with anticancer activity. MitoCur-1 induces massive reactive oxygen species production in cancer cells, reduces mitochondrial membrane potential, and triggers cell cycle arrest and apoptosis. Meanwhile, MitoCur-1 inhibits the phosphorylation of Akt and STAT3, enhances ERK phosphorylation, and upregulates the expression of the pro-apoptotic protein BNIP3. Dedimethyl MitoCur-1 can be used in research related to breast cancer, cervical cancer, prostate cancer, and neuroblastoma[1][2][3][4].
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Dedimethyl MitoCur-1 | Dedimethyl MitoCur-1 is a mitochondria-targeted curcuminoid derived from MitoCur-1 (HY-150228) with anticancer activity. MitoCur-1 induces massive reactive oxygen species production in cancer cells, reduces mitochondrial membrane potential, and triggers cell cycle arrest and apoptosis. Meanwhile, MitoCur-1 inhibits the phosphorylation of Akt and STAT3, enhances ERK phosphorylation, and upregulates the expression of the pro-apoptotic protein BNIP3. Dedimethyl MitoCur-1 can be used in research related to breast cancer, cervical cancer, prostate cancer, and neuroblastoma. | |||||||||||||||||||||
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- [1]. Reddy CA, et al. Mitochondrial-targeted curcuminoids: a strategy to enhance bioavailability and anticancer efficacy of curcumin. PloS one. 2014;9(3):e89351.
- [2]. Zukowski E, et al. STAT3 modulates CD4 T mitochondrial dynamics and function in aging. Aging cell. 2023 Nov;22(11):e13996.
- [3]. Zheng YL, et al. Redox-Based Strategy for Selectively Inducing Energy Crisis Inside Cancer Cells: An Example of Modifying Dietary Curcumin to Target Mitochondria. Journal of agricultural and food chemistry. 2022 Mar 09;70(9):2898-2910. [Content Brief]
- [4]. Li G, et al. MitoCur-1 induces ferroptosis to reverse vemurafenib resistance in melanoma through inhibition of USP14. Pigment cell & melanoma research. 2024 Mar;37(2):316-328.
Keywords
