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Cat. No.: HY-184665

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Dedimethyl MitoCur-1

Dedimethyl MitoCur-1 is a mitochondria-targeted curcuminoid derived from MitoCur-1 (HY-150228) with anticancer activity. MitoCur-1 induces massive reactive oxygen species production in cancer cells, reduces mitochondrial membrane potential, and triggers cell cycle arrest and apoptosis. Meanwhile, MitoCur-1 inhibits the phosphorylation of Akt and STAT3, enhances ERK phosphorylation, and upregulates the expression of the pro-apoptotic protein BNIP3. Dedimethyl MitoCur-1 can be used in research related to breast cancer, cervical cancer, prostate cancer, and neuroblastoma.

For research use only. We do not sell to patients.

CAS No.: 1638811-35-4
Formula: C₆₃H₆₀Cl₂O₆P₂
Molecular Weight:1046.00

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dedimethyl MitoCur-1 Chemical Structure

CAS No.: 1638811-35-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

Chemical Information

CAS No. 1638811-35-4
Molecular Weight 1046.00
Formula C₆₃H₆₀Cl₂O₆P₂
SMILES

COC(C=C(C=C1)/C=C/C(CC(/C=C/C2=CC(OC)=C(C=C2)OCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O)=O)=C1OCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8.[Cl-].[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Reddy CA, et al. Mitochondrial-targeted curcuminoids: a strategy to enhance bioavailability and anticancer efficacy of curcumin. PloS one. 2014;9(3):e89351. [Content Brief]

[2]. Zukowski E, et al. STAT3 modulates CD4 T mitochondrial dynamics and function in aging. Aging cell. 2023 Nov;22(11):e13996. [Content Brief]

[3]. Zheng YL, et al. Redox-Based Strategy for Selectively Inducing Energy Crisis Inside Cancer Cells: An Example of Modifying Dietary Curcumin to Target Mitochondria. Journal of agricultural and food chemistry. 2022 Mar 09;70(9):2898-2910. [Content Brief]

[4]. Li G, et al. MitoCur-1 induces ferroptosis to reverse vemurafenib resistance in melanoma through inhibition of USP14. Pigment cell & melanoma research. 2024 Mar;37(2):316-328. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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