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Cat. No.: HY-184665

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Dedimethyl MitoCur-1

Dedimethyl MitoCur-1 is a mitochondria-targeted curcuminoid derived from MitoCur-1 (HY-150228) with anticancer activity. MitoCur-1 induces massive reactive oxygen species production in cancer cells, reduces mitochondrial membrane potential, and triggers cell cycle arrest and apoptosis. Meanwhile, MitoCur-1 inhibits the phosphorylation of Akt and STAT3, enhances ERK phosphorylation, and upregulates the expression of the pro-apoptotic protein BNIP3. Dedimethyl MitoCur-1 can be used in research related to breast cancer, cervical cancer, prostate cancer, and neuroblastoma.

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CAS No.: 1638811-35-4
화학식: C₆₃H₆₀Cl₂O₆P₂
분자량:1046.00

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dedimethyl MitoCur-1 Chemical Structure

CAS No.: 1638811-35-4

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	5.1 μM Compound: Mitocur-1	Cytotoxicity against human DU-145 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay Cytotoxicity against human DU-145 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay	[PMID: 33479681]
HeLa	IC₅₀	4.46 μM Compound: Mitocur-1	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay	[PMID: 33479681]
MCF7	IC₅₀	2.31 μM Compound: Mitocur-1	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay	[PMID: 33479681]
MDA-MB-231	IC₅₀	5.1 μM Compound: Mitocur-1	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay	[PMID: 33479681]
SK-N-SH	IC₅₀	5.12 μM Compound: Mitocur-1	Cytotoxicity against human SK-N-SH cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay Cytotoxicity against human SK-N-SH cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay	[PMID: 33479681]

Chemical Information

CAS No. 1638811-35-4
분자량 1046.00
화학식 C₆₃H₆₀Cl₂O₆P₂
SMILES

COC(C=C(C=C1)/C=C/C(CC(/C=C/C2=CC(OC)=C(C=C2)OCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O)=O)=C1OCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8.[Cl-].[Cl-]
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Reddy CA, et al. Mitochondrial-targeted curcuminoids: a strategy to enhance bioavailability and anticancer efficacy of curcumin. PloS one. 2014;9(3):e89351. [Content Brief]

[2]. Zukowski E, et al. STAT3 modulates CD4 T mitochondrial dynamics and function in aging. Aging cell. 2023 Nov;22(11):e13996. [Content Brief]

[3]. Zheng YL, et al. Redox-Based Strategy for Selectively Inducing Energy Crisis Inside Cancer Cells: An Example of Modifying Dietary Curcumin to Target Mitochondria. Journal of agricultural and food chemistry. 2022 Mar 09;70(9):2898-2910. [Content Brief]

[4]. Li G, et al. MitoCur-1 induces ferroptosis to reverse vemurafenib resistance in melanoma through inhibition of USP14. Pigment cell & melanoma research. 2024 Mar;37(2):316-328. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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