Dedimethyl MitoCur-1
Dedimethyl MitoCur-1 is a mitochondria-targeted curcuminoid derived from MitoCur-1 (HY-150228) with anticancer activity. MitoCur-1 induces massive reactive oxygen species production in cancer cells, reduces mitochondrial membrane potential, and triggers cell cycle arrest and apoptosis. Meanwhile, MitoCur-1 inhibits the phosphorylation of Akt and STAT3, enhances ERK phosphorylation, and upregulates the expression of the pro-apoptotic protein BNIP3. Dedimethyl MitoCur-1 can be used in research related to breast cancer, cervical cancer, prostate cancer, and neuroblastoma.
For research use only. We do not sell to patients.
- CAS No.: 1638811-35-4
- Formula: C63H60Cl2O6P2
- Molecular Weight:1046.00
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
5.1 μM
Compound: Mitocur-1
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Cytotoxicity against human DU-145 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
Cytotoxicity against human DU-145 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
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[PMID: 33479681] |
| HeLa | IC50 |
4.46 μM
Compound: Mitocur-1
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
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[PMID: 33479681] |
| MCF7 | IC50 |
2.31 μM
Compound: Mitocur-1
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
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[PMID: 33479681] |
| MDA-MB-231 | IC50 |
5.1 μM
Compound: Mitocur-1
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
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[PMID: 33479681] |
| SK-N-SH | IC50 |
5.12 μM
Compound: Mitocur-1
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Cytotoxicity against human SK-N-SH cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
Cytotoxicity against human SK-N-SH cells assessed as reduction in cell viability incubated for 24 hrs by SRB assay
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[PMID: 33479681] |
Chemical Information
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CAS No. 1638811-35-4
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Molecular Weight 1046.00
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Formula C63H60Cl2O6P2
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SMILES
COC(C=C(C=C1)/C=C/C(CC(/C=C/C2=CC(OC)=C(C=C2)OCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O)=O)=C1OCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8.[Cl-].[Cl-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Reddy CA, et al. Mitochondrial-targeted curcuminoids: a strategy to enhance bioavailability and anticancer efficacy of curcumin. PloS one. 2014;9(3):e89351. [Content Brief]
[2]. Zukowski E, et al. STAT3 modulates CD4 T mitochondrial dynamics and function in aging. Aging cell. 2023 Nov;22(11):e13996. [Content Brief]
[3]. Zheng YL, et al. Redox-Based Strategy for Selectively Inducing Energy Crisis Inside Cancer Cells: An Example of Modifying Dietary Curcumin to Target Mitochondria. Journal of agricultural and food chemistry. 2022 Mar 09;70(9):2898-2910. [Content Brief]
[4]. Li G, et al. MitoCur-1 induces ferroptosis to reverse vemurafenib resistance in melanoma through inhibition of USP14. Pigment cell & melanoma research. 2024 Mar;37(2):316-328. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dedimethyl MitoCur-1 Related Classifications
HY-184665 Related Classifications
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