1801746-41-7
Chemical Structure
Isostrictiniin
Synonym(s): ITN
- CAS No.: 1801746-41-7
- Formula:C27H22O18
- Molecular Weight:634.45
InChIKey: MBPYHNAWMKVREM-BDYNXYCRSA-N
SMILES: OC1=C2C3=C(O)C(O)=C(O)C=C3C(O[C@]4([H])[C@@]([C@@H]([C@H](O[C@H]4OC(C5=CC(O)=C(C(O)=C5)O)=O)CO)O)([H])OC(C2=CC(O)=C1O)=O)=O
Biological Activity: Isostrictiniin (ITN) is a polyphenolic compound isolated from Nymphaea candida. It upregulates the expression of Nrf2 and HO-1, while downregulating the expression of Keap1. Isostrictiniin reduces the phosphorylation levels of JNK, ERK1/2, p38, IκBα, and NF-κB p65. Isostrictiniin decreases the levels of pro-inflammatory mediators (IL-1β, IL-6, TNF-α, PGE2). Isostrictiniin alleviates LPS-induced acute lung injury and exerts protective effects against acute alcoholic liver injury. Additionally, isostrictiniin exhibits anti-inflammatory, antioxidant, and anti-fibrotic activities.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Isostrictiniin | Isostrictiniin (ITN) is a polyphenolic compound isolated from Nymphaea candida. It upregulates the expression of Nrf2 and HO-1, while downregulating the expression of Keap1. Isostrictiniin reduces the phosphorylation levels of JNK, ERK1/2, p38, IκBα, and NF-κB p65. Isostrictiniin decreases the levels of pro-inflammatory mediators (IL-1β, IL-6, TNF-α, PGE2). Isostrictiniin alleviates LPS-induced acute lung injury and exerts protective effects against acute alcoholic liver injury. Additionally, isostrictiniin exhibits anti-inflammatory, antioxidant, and anti-fibrotic activities. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
