329016-45-7
Chemical Structure
CP-615003
Synonym(s): NGD-913
- CAS No.: 329016-45-7
- Formula:C20H24FN3O3
- Molecular Weight:373.42
InChIKey: YZHJISPIBWKWGY-UHFFFAOYSA-N
SMILES: O=C(C1=CNC2=C1C(CCC2)=O)NC3=CC=C(C(F)=C3)OCCNCCC
Biological Activity: CP-615003 is a potent and subtype-selective partial agonist of GABAA receptor (GABAA receptor) (Ki = 1.1 μM). CP-615003 is mainly converted into the active metabolite CP-900725 through oxidative deamination in monkeys and humans, and the latter also has GABAA receptor affinity. CP-615003 is a substrate of P-glycoprotein (P-gp/MDR1), resulting in severe limitation of its penetration into the central nervous system (CNS). CP-615003 can be used for the study of CNS-related indications[1].
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CP-615003 | CP-615003 is a potent and subtype-selective partial agonist of GABAA receptor (GABAA receptor) (Ki = 1.1 μM). CP-615003 is mainly converted into the active metabolite CP-900725 through oxidative deamination in monkeys and humans, and the latter also has GABAA receptor affinity. CP-615003 is a substrate of P-glycoprotein (P-gp/MDR1), resulting in severe limitation of its penetration into the central nervous system (CNS). CP-615003 can be used for the study of CNS-related indications. | |||||||||||||||||||||
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