338736-46-2
Chemical Structure
LY456236
- CAS No.: 338736-46-2
- Formula:C16H16ClN3O2
- Molecular Weight:317.78
IUPAC Name: 6-methoxy-N-(4-methoxyphenyl)quinazolin-4-amine hydrochloride
InChIKey: AVKFOWUSTVWZQN-UHFFFAOYSA-N
SMILES: COC1=CC=C(NC2=C3C=C(OC)C=CC3=NC=N2)C=C1.[H]Cl
Biological Activity: LY456236 is a selective, non-competitive and orally active antagonist of glutamate receptor 1 (mGlu1), which can inhibit phosphatidylinositol hydrolysis with an IC50 of 0.145 μM. LY456236 can also inhibit EGFR, with an IC50 of 0.918 μM. LY456236 blocks cell proliferation by inhibiting the MAPK pathway, reversing the anti-apoptotic effect of DHPG (HY-12598A). LY456236 can be used in epilepsy research[1][2][3].
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LY456236 | 99.57% | LY456236 is a selective, non-competitive and orally active antagonist of glutamate receptor 1 (mGlu1), which can inhibit phosphatidylinositol hydrolysis with an IC50 of 0.145 μM. LY456236 can also inhibit EGFR, with an IC50 of 0.918 μM. LY456236 blocks cell proliferation by inhibiting the MAPK pathway, reversing the anti-apoptotic effect of DHPG (HY-12598A). LY456236 can be used in epilepsy research. | ||||||||||||||||||||
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LY456236 (Standard) | ≥98% | LY456236 (Standard) is the analytical standard of LY456236 (HY-103566). This product is intended for research and analytical applications. LY456236 is a selective, non-competitive and orally active antagonist of glutamate receptor 1 (mGlu1), which can inhibit phosphatidylinositol hydrolysis with an IC50 of 0.145 μM. LY456236 can also inhibit EGFR, with an IC50 of 0.918 μM. LY456236 has anticonvulsant effects and blocks cell proliferation by inhibiting the MAPK pathway, reversing the anti-apoptotic effect of DHPG (HY-12598A). LY456236 can be used in epilepsy research. | ||||||||||||||||||||
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Similarity Score 0.98
HY-103566ALY456236 free base -
Similarity Score 0.79
HY-138222JANEX-1 hydrochloride -
Similarity Score 0.79
HY-15508JANEX-1 -
Similarity Score 0.77
HY-169851JANEX-1-M -
Similarity Score 0.77
HY-108419RWHI-P258 (Standard) -
Similarity Score 0.76
HY-178740GI261520A -
Similarity Score 0.75
HY-129037BCRP-IN-1 -
Similarity Score 0.75
HY-15769WHI-P180 -
Similarity Score 0.75
HY-15769AWHI-P180 hydrochloride -
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References
- [1]. Ravikumar B, et al. Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies. Cell Chem Biol. 2019 Nov 21;26(11):1608-1622.e6. [Content Brief]
- [2]. Kanaya S, et al. Metabotropic glutamate receptor 1 promotes cementoblast proliferation via MAP kinase signaling pathways. Connect Tissue Res. 2016 Sep;57(5):417-26. [Content Brief]
- [3]. Shannon HE, et al. Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist. Neuropharmacology. 2005;49 Suppl 1:188-95. [Content Brief]
