497-23-4
Chemical Structure
2(5H)-Furanone
Synonym(s): γ-Crotonolactone
- CAS No.: 497-23-4
- Formula:C4H4O2
- Molecular Weight:84.07
IUPAC Name: furan-2(5H)-one
InChIKey: VIHAEDVKXSOUAT-UHFFFAOYSA-N
SMILES: O=C1OCC=C1
Biological Activity: 2(5H)-Furanone (γ-Crotonolactone) is an endogenous metabolite. 2(5H)-Furanone mimics N-acyl homoserine lactone signals, occupies the binding site of LuxR homologs, and interferes with quorum sensing-mediated gene regulation. 2(5H)-Furanone inhibits quorum sensing mediated by AHLs with different acyl chain lengths. 2(5H)-Furanone inhibits biofilm formation of environmental Aeromonas hydrophila strains on polystyrene plates. 2(5H)-Furanone suppresses spike-and-wave discharges in a rat model of generalized absence seizures and exhibits selective activity against absence seizures. 2(5H)-Furanone can be used in studies related to bacteria infections and generalized absence seizures.[1][2]
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2(5H)-Furanone | 99.94% | 2(5H)-Furanone (γ-Crotonolactone) is an endogenous metabolite. 2(5H)-Furanone mimics N-acyl homoserine lactone signals, occupies the binding site of LuxR homologs, and interferes with quorum sensing-mediated gene regulation. 2(5H)-Furanone inhibits quorum sensing mediated by AHLs with different acyl chain lengths. 2(5H)-Furanone inhibits biofilm formation of environmental Aeromonas hydrophila strains on polystyrene plates. 2(5H)-Furanone suppresses spike-and-wave discharges in a rat model of generalized absence seizures and exhibits selective activity against absence seizures. 2(5H)-Furanone can be used in studies related to bacteria infections and generalized absence seizures. | ||||||||||||||||||||
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2(5H)-Furanone (Standard) | ≥98% | 2(5H)-Furanone (Standard) is the analytical standard of 2(5H)-Furanone. This product is intended for research and analytical applications. 2(5H)-Furanone (γ-Crotonolactone) is an endogenous metabolite. 2(5H)-Furanone mimics N-acyl homoserine lactone signals, occupies the binding site of LuxR homologs, and interferes with quorum sensing-mediated gene regulation. 2(5H)-Furanone inhibits quorum sensing mediated by AHLs with different acyl chain lengths. 2(5H)-Furanone inhibits biofilm formation of environmental Aeromonas hydrophila strains on polystyrene plates. 2(5H)-Furanone suppresses spike-and-wave discharges in a rat model of generalized absence seizures and exhibits selective activity against absence seizures. 2(5H)-Furanone can be used in studies related to bacteria infections and generalized absence seizures. | ||||||||||||||||||||
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- [1]. Ponnusamy K, et al. 2(5H)-Furanone: A Prospective strategy for biofouling-control in membrane biofilm bacteria by quorum sensing inhibition. Braz J Microbiol. 2010 Jan;41(1):227-34. [Content Brief]
- [2]. Snead OC 3rd, et al. Effect of gamma-crotonolactone in experimental models of generalized absence seizures. Brain Res. 1991;543(1):10-14. [Content Brief]
