54-92-2
54-92-2
Chemical Structure
Iproniazid
- CAS No.: 54-92-2
- Formula:C9H13N3O
- Molecular Weight:179.22
IUPAC Name: N'-isopropylisonicotinohydrazide
InChIKey: NYMGNSNKLVNMIA-UHFFFAOYSA-N
SMILES: O=C(C1=CC=NC=C1)NNC(C)C
Biological Activity: Iproniazid is an orally active, irreversible, non-selective monoamine oxidase (MAO) inhibitor. Iproniazid inhibits MAO activity and enhances Rotenone (HY-B1756)-induced Apoptosis. Iproniazid modulates neurotransmitter levels, affects neuronal function, induces hepatic necrosis, and interferes with the endocrine system. Iproniazid can be used in the research of depression, Parkinson's disease, and hepatotoxicity[1][2][3][4][5][6][7].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Iproniazid | 99.91% | Iproniazid is an orally active, irreversible, non-selective monoamine oxidase (MAO) inhibitor. Iproniazid inhibits MAO activity and enhances Rotenone (HY-B1756)-induced Apoptosis. Iproniazid modulates neurotransmitter levels, affects neuronal function, induces hepatic necrosis, and interferes with the endocrine system. Iproniazid can be used in the research of depression, Parkinson's disease, and hepatotoxicity. | ||||||||||||||||||||
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Iproniazid (Standard) | ≥98% | Iproniazid (Standard) is the analytical standard of Iproniazid (HY-B0886A). This product is intended for research and analytical applications. Iproniazid is an orally active, irreversible, non-selective monoamine oxidase (MAO) inhibitor. Iproniazid inhibits MAO activity and enhances Rotenone (HY-B1756)-induced Apoptosis. Iproniazid modulates neurotransmitter levels, affects neuronal function, induces hepatic necrosis, and interferes with the endocrine system. Iproniazid can be used in the research of depression, Parkinson's disease, and hepatotoxicity. | ||||||||||||||||||||
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Acetylisoniazid | 99.66% | Acetylisoniazid is a primary Isoniazid (HY-B0329) metabolite mediated by N-acetyltransferase (NAT). Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity. | ||||||||||||||||||||
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N-Methylnicotinamide | 99.79% | N-Methylnicotinamide is an endogenous metabolite with antithrombotic effect. N-Methylnicotinamide via production/release of prostacyclin inhibits arterial thrombosis development. N-Methylnicotinamide is also the N-methylation product from nicotinamide catalyzed by N-methyltransferase within nicotinate and nicotinamide metabolism pathway. | ||||||||||||||||||||
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Crotoniazide | Crotoniazide (compound 9) is an isonicotinic acid hydrazide derivative with anti-HIV potential with an EC50 value of 11 ug/mL. | |||||||||||||||||||||
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Isoniazid (Standard) | 99.77% | Isoniazid (Standard) is the analytical standard of Isoniazid. This product is intended for research and analytical applications. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity. | ||||||||||||||||||||
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Nicotinohydrazide | 99.35% | Nicotinohydrazide (Nicotinic acid hydrazide) is a precursor used for synthesizing hydrazone derivatives with antibacterial and antifungal activities. Nicotinohydrazide can be used in studies of bacterial and fungal infections. | ||||||||||||||||||||
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Isonicotinamide (Standard) | 99.75% | Isonicotinamide (Standard) is the analytical standard of Isonicotinamide. This product is intended for research and analytical applications. Isonicotinamide is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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4-Formyl-N-isopropylbenzamide (Standard) | ≥98% | 4-Formyl-N-isopropylbenzamide (Standard) is the analytical standard of 4-Formyl-N-isopropylbenzamide. This product is intended for research and analytical applications. | ||||||||||||||||||||
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N-Ethylnicotinamide | 99.52% | N-Ethylnicotinamide is a compound with weak vasodilatory activity. N-Ethylnicotinamide also serves as the core scaffold of the antianginal agent Nicorandil (HY-B0341) and its derivatives. | ||||||||||||||||||||
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4-Acetylpyridine | 99.98% | 4-Acetylpyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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Nicotinamide Impurity 4 (Standard) | ≥98% | Nicotinamide Impurity 4 (Standard) is the analytical standard of Nicotinamide Impurity 4. This product is intended for research and analytical applications. | ||||||||||||||||||||
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References
- [1]. Fagervall I, et al. Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors. Biochemical pharmacology 35 (8): 1381–1387
- [2]. Watabe M, et al. Mitochondrial complex I inhibitor rotenone-elicited dopamine redistribution from vesicles to cytosol in human dopaminergic SH-SY5Y cells. J Pharmacol Exp Ther. 2007 Nov;323(2):499-507. [Content Brief]
- [3]. Dodson AM, et al. Serotonin uptake and metabolism by cultured guinea pig airway smooth muscle cells. Pulm Pharmacol Ther. 2004;17(1):19-25. [Content Brief]
- [4]. De Oliveira LF, et al. Effects of 5-hydroxytryptophan, iproniazid and p-chlorophenylalanine on lidocaine seizure threshold of mice. Eur J Pharmacol. 1974 Nov;29(1):5-9. [Content Brief]
- [5]. Nelson SD, et al. Hepatotoxicity and metabolism of iproniazid and isopropylhydrazine. J Pharmacol Exp Ther. 1978 Sep;206(3):574-85. [Content Brief]
- [6]. SETNIKAR I V O, et al. Retardation of sexual development in female rats due to iproniazid treatment. Endocrinology, 1960, 67(4): 511-520.
- [7]. Huang J T, et al. The effect of pretreatment with iproniazid on the behavioral activities of β-phenylethylamine in rats. Psychopharmacologia, 1974, 35(1): 77-81.
