57744-69-1
Chemical Structure
Aspulvinone H
- CAS No.: 57744-69-1
- Formula:C27H28O5
- Molecular Weight:432.51
IUPAC Name: (Z)-4-hydroxy-5-(4-hydroxy-3-(3-methylbut-2-en-1-yl)benzylidene)-3-(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)furan-2(5H)-one
InChIKey: LFDYHAWYVIBCDT-OYKKKHCWSA-N
SMILES: OC1=C(C2=CC(C/C=C(C)\C)=C(C=C2)O)C(O/C1=C\C3=CC(C/C=C(C)\C)=C(C=C3)O)=O
Biological Activity: Aspulvinone H is an orally active inhibitor of AChE, pancreatic lipase, glutamic-oxaloacetic transaminase 1, and α-glucosidase, with IC50 values of 25.95 μM, 47.06 μM, 5.91/6.91 μM, and 4.6 μM, respectively. It has a Ka of 2.14 μM against GOT1 and a Ki of 6.58 μM against α-glucosidase. Aspulvinone H inhibits cancer cell proliferation, interferes with glutamine metabolism, elevates ROS levels, and induces cell apoptosis and S-phase arrest. Aspulvinone H exhibits antibacterial activity against Staphylococcus aureus. Aspulvinone H inhibits the growth of pancreatic ductal adenocarcinoma xenografts. Aspulvinone H reduces postprandial blood glucose in mice. Aspulvinone H can be used in research related to pancreatic ductal adenocarcinoma, diabetes, and Staphylococcus aureus infection[1][2][3][4].
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Aspulvinone H | Aspulvinone H is an orally active inhibitor of AChE, pancreatic lipase, glutamic-oxaloacetic transaminase 1, and α-glucosidase, with IC50 values of 25.95 μM, 47.06 μM, 5.91/6.91 μM, and 4.6 μM, respectively. It has a Ka of 2.14 μM against GOT1 and a Ki of 6.58 μM against α-glucosidase. Aspulvinone H inhibits cancer cell proliferation, interferes with glutamine metabolism, elevates ROS levels, and induces cell apoptosis and S-phase arrest. Aspulvinone H exhibits antibacterial activity against Staphylococcus aureus. Aspulvinone H inhibits the growth of pancreatic ductal adenocarcinoma xenografts. Aspulvinone H reduces postprandial blood glucose in mice. Aspulvinone H can be used in research related to pancreatic ductal adenocarcinoma, diabetes, and Staphylococcus aureus infection. | |||||||||||||||||||||
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References
- [1]. Qi X, et al. A glyoxylate-containing benzene derivative and butenolides from a marine algicolous fungus Aspergillus sp. SCSIO 41304. Nat Prod Res. 2023;37(3):441-448. [Content Brief]
- [2]. Yan S, et al. Discovery of GOT1 Inhibitors from a Marine-Derived Aspergillus terreus That Act against Pancreatic Ductal Adenocarcinoma. Mar Drugs. 2021 Oct 20;19(11):588. [Content Brief]
- [3]. Wu C, et al. Aspulvinones Suppress Postprandial Hyperglycemia as Potent α-Glucosidase Inhibitors From Aspergillus terreus ASM-1. Front Chem. 2021 Aug 17;9:736070. [Content Brief]
- [4]. Nagia MM, et al. Four butyrolactones and diverse bioactive secondary metabolites from terrestrial Aspergillus flavipes MM2: isolation and structure determination. Org Med Chem Lett. 2012;2(1):9. Published 2012 Mar 1. [Content Brief]
