76551-65-0
Chemical Structure
Partricin B
- CAS No.: 76551-65-0
- Formula:C58H84N2O19
- Molecular Weight:1113.29
InChIKey: NVJUPMZQNWDHTL-ACIZXYNNSA-N
SMILES: O=C(O[C@H]([C@@H](C)CC[C@@H](O)CC(C1=CC=C(N)C=C1)=O)[C@@H](C)/C=C/C=C/C=C\C=C/C=C/C=C/C=C/[C@H](O[C@H]2[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O2)C3)C[C@H](O)CC(C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@]4(O)C[C@H](O)[C@@H](C(O)=O)[C@H]3O4)=O
Biological Activity: Partricin B is an aromatic heptaene macrolide with antifungal and antiprotozoal activities. Partricin B interacts with cholesterol via the polyene side of the plane of its macrolide ring; its all-trans photoisomer interacts with cholesterol via the opposite region and shows no tendency to bind to the polyene region. Partricin B can be used in studies related to fungal infections[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Partricin B | Partricin B is an aromatic heptaene macrolide with antifungal and antiprotozoal activities. Partricin B interacts with cholesterol via the polyene side of the plane of its macrolide ring; its all-trans photoisomer interacts with cholesterol via the opposite region and shows no tendency to bind to the polyene region. Partricin B can be used in studies related to fungal infections. | |||||||||||||||||||||
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- [1]. Borzyszkowska-Bukowska J, et al. Antibiotic-sterol interactions provide insight into the selectivity of natural aromatic analogues of amphotericin B and their photoisomers. Scientific reports. 2023 Jan 14;13(1):762. [Content Brief]
- [2]. Szczeblewski P, et al. Iso-Partricin, an Aromatic Analogue of Amphotericin B: How Shining Light on Old Drugs Might Help Create New Ones. Antibiotics (Basel, Switzerland). 2021 Sep 13;10(9):1102. [Content Brief]
- [3]. Tweit RC, et al. Characterization of the antifungal and antiprotozoal antibiotic partricin and structural studies on partricins A and B. The Journal of antibiotics. 1982 Aug;35(8):997-1012. [Content Brief]
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