84000-07-7
84000-07-7
Chemical Structure
Fmoc-N-Me-Ala-OH
- CAS No.: 84000-07-7
- Formula:C19H19NO4
- Molecular Weight:325.36
IUPAC Name: N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-methyl-L-alanine
InChIKey: JOFHWKQIQLPZTC-LBPRGKRZSA-N
SMILES: C[C@H](N(C(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)C)C(O)=O
Biological Activity: Fmoc-N-Me-Ala-OH is an Fmoc-protected N-methyl-L-alanine and also a building block for solid-phase peptide synthesis. As a building block, Fmoc-N-Me-Ala-OH is used to synthesize peptidomimetic antagonists of XIAP BIR3 derived from Smac/DIABLO[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Fmoc-N-Me-Ala-OH | 99.92% | Fmoc-N-Me-Ala-OH is an Fmoc-protected N-methyl-L-alanine and also a building block for solid-phase peptide synthesis. As a building block, Fmoc-N-Me-Ala-OH is used to synthesize peptidomimetic antagonists of XIAP BIR3 derived from Smac/DIABLO. | ||||||||||||||||||||
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References
- [1]. Udompholkul P, et al. Lysine Covalent Antagonists of Melanoma Inhibitors of Apoptosis Protein. J Med Chem. 2021;64(21):16147-16158. [Content Brief]
- [2]. Elsawy MA, et al. Solid phase synthesis of Smac/DIABLO-derived peptides using a 'Safety-Catch' resin: identification of potent XIAP BIR3 antagonists. Bioorg Med Chem. 2013;21(17):5004-5011. [Content Brief]
- [3]. Szloszár A, et al. Sustainable synthesis of N-methylated peptides in a continuous-flow fixed bed reactor[J]. Journal of Flow Chemistry, 2018, 8(1): 21-27.
