869901-69-9
Chemical Structure
MK-2048
- CAS No.: 869901-69-9
- Formula:C21H21ClFN5O4
- Molecular Weight:461.87
IUPAC Name: (S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide
InChIKey: JSRREMIKIHJGAA-JTQLQIEISA-N
SMILES: FC1=C(Cl)C=C(CN2C(C(C(O)=C3N4[C@@H](C)CN(CC)C3=O)=C4C(C(NC)=O)=N2)=O)C=C1
Biological Activity: MK-2048 is a HIV-1 and HIV-1 integrase inhibitor. MK-2048 shows selective activity against HTLV-1-infected cells and retained potency against HIV-1 variants. MK-2048 induces apoptosis, inhibits cell growth, reduces proviral loads, and blocks HTLV-1 transmission and immortalization. MK-2048 can be used for the research of HIV-1 infection[1][2][3][4].
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MK-2048 | MK-2048 is a HIV-1 and HIV-1 integrase inhibitor. MK-2048 shows selective activity against HTLV-1-infected cells and retained potency against HIV-1 variants. MK-2048 induces apoptosis, inhibits cell growth, reduces proviral loads, and blocks HTLV-1 transmission and immortalization. MK-2048 can be used for the research of HIV-1 infection. | |||||||||||||||||||||
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References
- [1]. Ikebe E, et al. PS932 HIV INTEGRASE INHIBITOR MK-2048 INDUCES APOPTOSIS IN HTLV-1 INFECTED CELLS THROUGH THE UPR ACTIVATION[J]. HemaSphere, 2019, 3(S1): 420.
- [2]. Seegulam ME, et al. Integrase inhibitors effective against human T-cell leukemia virus type 1. Antimicrob Agents Chemother. 2011;55(5):2011-2017. [Content Brief]
- [3]. Bar-Magen T, et al. Identification of novel mutations responsible for resistance to MK-2048, a second-generation HIV-1 integrase inhibitor. J Virol. 2010;84(18):9210-9216. [Content Brief]
- [4]. Tong X, et al. Development and Evaluation of Nanoparticles-in-Film Technology to Achieve Extended In Vivo Exposure of MK-2048 for HIV Prevention. Polymers (Basel). 2022;14(6):1196. Published 2022 Mar 16. [Content Brief]
