90348-29-1
Chemical Structure
5-Nitro-1H-indazole-3-carbonitrile
Synonym(s): DL0805
- CAS No.: 90348-29-1
- Formula:C8H4N4O2
- Molecular Weight:188.14
IUPAC Name: 5-nitro-1H-indazole-3-carbonitrile
InChIKey: WXTZAAHDBOKXDI-UHFFFAOYSA-N
SMILES: N#CC1=NNC2=C1C=C([N+]([O-])=O)C=C2
Biological Activity: 5-Nitro-1H-indazole-3-carbonitrile (DL0805) is a Rho kinase(ROCK) inhibitor with an IC50 of 6.67 μM for ROCK-I. 5-Nitro-1H-indazole-3-carbonitrile reduces Norepinephrine (HY-13715)-induced transient contraction and inhibits contraction induced by increasing external calcium in the endothelium-denuded rings of rat models. 5-Nitro-1H-indazole-3-carbonitrile has a vasorelaxant activity but high toxicity. 5-Nitro-1H-indazole-3-carbonitrile can be used for cardiovascular diseases, especially hypertension research[1][2].
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5-Nitro-1H-indazole-3-carbonitrile | 5-Nitro-1H-indazole-3-carbonitrile (DL0805) is a Rho kinase(ROCK) inhibitor with an IC50 of 6.67 μM for ROCK-I. 5-Nitro-1H-indazole-3-carbonitrile reduces Norepinephrine (HY-13715)-induced transient contraction and inhibits contraction induced by increasing external calcium in the endothelium-denuded rings of rat models. 5-Nitro-1H-indazole-3-carbonitrile has a vasorelaxant activity but high toxicity. 5-Nitro-1H-indazole-3-carbonitrile can be used for cardiovascular diseases, especially hypertension research. | |||||||||||||||||||||
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References
- [1]. Yuan TY, et al. DL0805-2, a novel indazole derivative, relaxes angiotensin II-induced contractions of rat aortic rings by inhibiting Rho kinase and calcium fluxes. Acta Pharmacol Sin. 2016 May;37(5):604-16. [Content Brief]
- [2]. Gong L, et al. The vasorelaxant mechanisms of a Rho kinase inhibitor DL0805 in rat thoracic aorta. Molecules. 2012 May 18;17(5):5935-44. [Content Brief]
