2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton
  3. ROCK
  4. 5-Nitro-1H-indazole-3-carbonitrile

5-Nitro-1H-indazole-3-carbonitrile  (Synonyms: DL0805)

Cat. No.: HY-W047432
Handling Instructions Technical Support

5-Nitro-1H-indazole-3-carbonitrile (DL0805) is a Rho kinase(ROCK) inhibitor with an IC50 of 6.67 μM for ROCK-I. 5-Nitro-1H-indazole-3-carbonitrile reduces Norepinephrine (HY-13715)-induced transient contraction and inhibits contraction induced by increasing external calcium in the endothelium-denuded rings of rat models. 5-Nitro-1H-indazole-3-carbonitrile has a vasorelaxant activity but high toxicity. 5-Nitro-1H-indazole-3-carbonitrile can be used for cardiovascular diseases, especially hypertension research.

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5-Nitro-1H-indazole-3-carbonitrile

5-Nitro-1H-indazole-3-carbonitrile 화학구조

CAS No. : 90348-29-1

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5-Nitro-1H-indazole-3-carbonitrile Related Antibodies

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제품 설명

5-Nitro-1H-indazole-3-carbonitrile (DL0805) is a Rho kinase(ROCK) inhibitor with an IC50 of 6.67 μM for ROCK-I. 5-Nitro-1H-indazole-3-carbonitrile reduces Norepinephrine (HY-13715)-induced transient contraction and inhibits contraction induced by increasing external calcium in the endothelium-denuded rings of rat models. 5-Nitro-1H-indazole-3-carbonitrile has a vasorelaxant activity but high toxicity. 5-Nitro-1H-indazole-3-carbonitrile can be used for cardiovascular diseases, especially hypertension research[1][2].

IC50 & Target[2]

ROCK-I

6.67 μM (IC50)

분자량

188.14

화학식

C8H4N4O2
CAS No.
SMILES

N#CC1=NNC2=C1C=C([N+]([O-])=O)C=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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5-Nitro-1H-indazole-3-carbonitrile Related Classifications

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Keywords:

5-Nitro-1H-indazole-3-carbonitrile90348-29-1DL0805DL 0805DL-0805ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKInhibitorTransient contractionEndothelium-denuded ringsVasorelaxantHigh toxicityHypertensioninhibitorinhibit

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상품명:
5-Nitro-1H-indazole-3-carbonitrile
Cat. No.:
HY-W047432
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