5-Nitro-1H-indazole-3-carbonitrile
5-Nitro-1H-indazole-3-carbonitrile (DL0805) is a Rho kinase(ROCK) inhibitor with an IC50 of 6.67 μM for ROCK-I. 5-Nitro-1H-indazole-3-carbonitrile reduces Norepinephrine (HY-13715)-induced transient contraction and inhibits contraction induced by increasing external calcium in the endothelium-denuded rings of rat models. 5-Nitro-1H-indazole-3-carbonitrile has a vasorelaxant activity but high toxicity. 5-Nitro-1H-indazole-3-carbonitrile can be used for cardiovascular diseases, especially hypertension research.
For research use only. We do not sell to patients.
- CAS No.: 90348-29-1
- Formula: C8H4N4O2
- Molecular Weight:188.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[2]|
ROCK-I 6.67 μM (IC50) |
Chemical Information
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CAS No. 90348-29-1
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Molecular Weight 188.14
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Formula C8H4N4O2
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SMILES
N#CC1=NNC2=C1C=C([N+]([O-])=O)C=C2
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Synonyms
DL0805
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Yuan TY, et al. DL0805-2, a novel indazole derivative, relaxes angiotensin II-induced contractions of rat aortic rings by inhibiting Rho kinase and calcium fluxes. Acta Pharmacol Sin. 2016 May;37(5):604-16. [Content Brief]
[2]. Gong L, et al. The vasorelaxant mechanisms of a Rho kinase inhibitor DL0805 in rat thoracic aorta. Molecules. 2012 May 18;17(5):5935-44. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5-Nitro-1H-indazole-3-carbonitrile Related Classifications
HY-W047432 Related Classifications
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