956189-58-5
Chemical Structure
LIN28 inhibitor LI71 enantiomer
- CAS No.: 956189-58-5
- Formula:C21H21NO3
- Molecular Weight:335.40
IUPAC Name: 4-((3aR,4S,9bS)-6-ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl)benzoic acid
InChIKey: QWJMABCFVYELBB-FRQCXROJSA-N
SMILES: O=C(O)C1=CC=C([C@H]2NC3=C(C=CC=C3OCC)[C@]4([H])[C@@]2([H])CC=C4)C=C1
Biological Activity: LIN28 inhibitor LI71 enantiomer is the less active enantiomer of LIN28 inhibitor LI71 (HY-123905). LIN28 inhibitor LI71 is a LIN28 inhibitor that effectively inhibits LIN28:let-7 binding (IC50: 7 μM). LIN28 inhibitor LI71 can abolish LIN28-mediated oligouridylation of let-7 precursor (IC50: 27 μM). LIN28 inhibitor LI71 has potential application value in LIN28-driven cancer research. LIN28 inhibitor LI71 inhibits the interaction of cold shock protein of Plasmodium falciparum (PfCoSP) with DNA and α/β tubulin and has an inhibitory effect on Plasmodium falciparum[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LIN28 inhibitor LI71 enantiomer | 99.68% | LIN28 inhibitor LI71 enantiomer is the less active enantiomer of LIN28 inhibitor LI71 (HY-123905). LIN28 inhibitor LI71 is a LIN28 inhibitor that effectively inhibits LIN28:let-7 binding (IC50: 7 μM). LIN28 inhibitor LI71 can abolish LIN28-mediated oligouridylation of let-7 precursor (IC50: 27 μM). LIN28 inhibitor LI71 has potential application value in LIN28-driven cancer research. LIN28 inhibitor LI71 inhibits the interaction of cold shock protein of Plasmodium falciparum (PfCoSP) with DNA and α/β tubulin and has an inhibitory effect on Plasmodium falciparum. | ||||||||||||||||||||
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- [1]. Wang L, et al. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018;23(10):3091-3101. [Content Brief]
- [2]. Behl A,et al. Targeting an essential Plasmodium cold shock protein to block growth and transmission of malaria parasite. iScience. 2023 Apr 11;26(5):106637. [Content Brief]
Keywords
