Art. -Nr.: HY-B0264

Guaifenesin

(Synonyms: Guaiacol glyceryl ether; Guaiphenesin; Glycerol guaiacolate)

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Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough.

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Reinheit: 99.86%
CAS. Nr.: 93-14-1
Formel: C₁₀H₁₄O₄
Molecular Weight:198.22

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Guaifenesin Chemical Structure

CAS. Nr.: 93-14-1

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Mucin Isoform-spezifische Produkte anzeigen :

MUC5AC
MUC1

In Vitro

Guaifenesin (2 or 20 µg/mL, 6-48 h) inhibits mucin release in epithelial cultures^[3].
Guaifenesin (10-300 μM, 3-24 h) inhibits IL-13-induced MUC5AC content and secretion in primary human airway epithelial cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Guaifenesin (50 mg/kg, p.o.; or 10 mg/kg, i.v.; rats) shows a t_1/2 of 45.6 h (p.o.), and 49.0 h (i.v.), AUC of 2469 (p.o.) and 711 (i.v.) μg·min/mL^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 93-14-1
Appearance Solid
Molecular Weight 198.22
Formel C₁₀H₁₄O₄
Color White to off-white
SMILES

OCC(O)COC1=CC=CC=C1OC
Synonyms

Guaiacol glyceryl ether; Guaiphenesin; Glycerol guaiacolate
Structure Classification
- Others
Initial Source
- Plants
- other families
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (504.49 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.0449 mL

25.2245 mL

50.4490 mL

5 mM

1.0090 mL

5.0449 mL

10.0898 mL

10 mM

0.5045 mL

2.5224 mL

5.0449 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Bennett, S., N. Hoffman, and M. Monga, Ephedrine- and guaifenesin-induced nephrolithiasis. J Altern Complement Med, 2004. 10(6): p. 967-9. [Content Brief]

[2]. Dicpinigaitis PV, et, al. Effect of guaifenesin on cough reflex sensitivity. Chest. 2003 Dec;124(6):2178-81. [Content Brief]

[3]. Seagrave J, et al. Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells. Exp Lung Res. 2011 Dec;37(10):606-14. [Content Brief]

[4]. Seagrave J, et al. Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cells. Respir Res. 2012 Oct 31;13(1):98. [Content Brief]

[5]. Kagan L,et al. Effect of mode of administration on guaifenesin pharmacokinetics and expectorant action in the rat model. Pulm Pharmacol Ther. 2009 Jun;22(3):260-5. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.0449 mL	25.2245 mL	50.4490 mL	126.1225 mL
	5 mM	1.0090 mL	5.0449 mL	10.0898 mL	25.2245 mL
	10 mM	0.5045 mL	2.5224 mL	5.0449 mL	12.6122 mL
	15 mM	0.3363 mL	1.6816 mL	3.3633 mL	8.4082 mL
	20 mM	0.2522 mL	1.2612 mL	2.5224 mL	6.3061 mL
	25 mM	0.2018 mL	1.0090 mL	2.0180 mL	5.0449 mL
	30 mM	0.1682 mL	0.8408 mL	1.6816 mL	4.2041 mL
	40 mM	0.1261 mL	0.6306 mL	1.2612 mL	3.1531 mL
	50 mM	0.1009 mL	0.5045 mL	1.0090 mL	2.5224 mL
	60 mM	0.0841 mL	0.4204 mL	0.8408 mL	2.1020 mL
	80 mM	0.0631 mL	0.3153 mL	0.6306 mL	1.5765 mL
	100 mM	0.0504 mL	0.2522 mL	0.5045 mL	1.2612 mL

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Guaifenesin

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Alle Mucin Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Guaifenesin Related Classifications

HY-B0264 Related Classifications