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Art. -Nr.: HY-148933

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ALKBH5-IN-2

ALKBH5-IN-2 (compound 6) is a potent ALKBH5 inhibitor with an IC₅₀ value of 0.79 µM. ALKBH5-IN-2 inhibits cell viability.

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CAS. Nr.: 1008951-10-7
Formel: C₉H₁₁N₃O₃
Molecular Weight:209.20

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

ALKBH5-IN-2 Chemical Structure

CAS. Nr.: 1008951-10-7

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

ALKBH5-IN-2 (compound 6) is a potent ALKBH5 inhibitor with an IC₅₀ value of 0.79 µM. ALKBH5-IN-2 inhibits cell viability^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	1.38 μM Compound: 121	Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 48 hrs Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 48 hrs	[PMID: 34792334]
HL-60	IC₅₀	1.38 μM Compound: 121	Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs	[PMID: 34792334]
K562	IC₅₀	1.38 μM Compound: 121	Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs	[PMID: 34792334]

In Vitro

ALKBH5-IN-2 (compound 6) (0-50µM; 48 h) inhibits cell viability with IC₅₀s of 40.5, 7.62, 11.0, 41.3, 1.41, >50 µM for HEK-293T, CCRF-CEM, HL-60, Jurkat, K562, A-172 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HEK-293T, CCRF-CEM, HL-60, Jurkat, K562, A-172 cells
Concentration:

0-50 µM
Incubation Time:

48 h
Result:

Inhibited cell growth with IC₅₀s of 40.5, 7.62, 11.0, 41.3, 1.41, >50 µM for HEK-293T, CCRF-CEM, HL-60, Jurkat, K562, A-172 cells, respectively.

Chemical Information

CAS. Nr. 1008951-10-7
Molecular Weight 209.20
Formel C₉H₁₁N₃O₃
SMILES

O=C1NNC(C(C1)NCC2=CC=CO2)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Selberg S, et al. Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors. ACS Omega. 2021 May 14;6(20):13310-13320. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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