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Art. -Nr.: HY-151567

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Antibacterial agent 123

Antibacterial agent 123 (compound 111) is a potent membrane-disrupting agent to combat antibiotic-resistant Gram-positive bacteria.

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CAS. Nr.: 2615254-55-0
Formel: C₁₇H₈F₉N₃O
Molecular Weight:441.25

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Antibacterial agent 123 Chemical Structure

CAS. Nr.: 2615254-55-0

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Antibacterial agent 123 (compound 111) is a potent membrane-disrupting agent to combat antibiotic-resistant Gram-positive bacteria^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Erythrocyte	CC₅₀	>32 μg/mL Compound: 111	Cytotoxicity against sheep erythrocytes assessed as reduction in cell viability Cytotoxicity against sheep erythrocytes assessed as reduction in cell viability	[PMID: 36219779]

In Vitro

Antibacterial agent 123 (compound 111) shows excellent activity (MIC<0.0625 μg/mL) toward S. aureus strains^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antibacterial agent 123 (compound 111) (p.o. (10 mg/kg) and i.v. (0.5 mg/kg); once) exhibits favorable pharmacokinetics profiles^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female CD-1 mice^[1]
Dosage:

0.5 mg/kg, 10 mg/kg
Administration:

p.o. (10 mg/kg) and i.v. (0.5 mg/kg); once (Pharmacokinetic Analysis)

Result:

Pharmacokinetic Parameters of Antibacterial agent 123 in Female CD-1 Mice^[1].

pharmacokinetic indices	dose i.v., p.o. (mg/kg)	AUC_0-24 (i.v., h·ng/mL)	Vd (i.v., mL/kg)	CL (i.v., mL/(kg·h))	t_1/2 (i.v., h)	AUC_0-24 (p.o., h·ng/mL)	C_max (p.o., ng/mL)	F (%)
compound 111	0.5, 10	(4.20 × 10³) ± 308	322 ± 24	119 ± 9.2	1.88 ± 0.08	(4.33 × 10⁴) ± 543	(3.10 × 10³) ± 780	51.6 ± 5.2

Chemical Information

CAS. Nr. 2615254-55-0
Molecular Weight 441.25
Formel C₁₇H₈F₉N₃O
SMILES

O=C1C=C(C(F)(F)F)NC2=C1C(NC3=NC=C(C(F)(F)F)C=C3)=CC(C(F)(F)F)=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Schultz JR, et al. Identification of 5-(Aryl/Heteroaryl)amino-4-quinolones as Potent Membrane-Disrupting Agents to Combat Antibiotic-Resistant Gram-Positive Bacteria. J Med Chem. 2022 Oct 11. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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