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Art. -Nr.: HY-181866

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Antibacterial agent 328

Antibacterial agent 328 is a enoyl-ACP reductase (InhA) inhibitor and antimycobacterial agent. Antibacterial agent 328 blocks mycolic acid biosynthesis in Mycobacterium tuberculosis. Antibacterial agent 328 acts on both drug-resistant and drug-susceptible Mycobacterium tuberculosis strains. Antibacterial agent 328 exhibits favorable pharmacokinetic properties, drug-likeness, and a safety-related selectivity index. Antibacterial agent 328 can be used for research on tuberculosis.

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CAS. Nr.: 2670430-25-6
Formel: C₁₈H₁₂BrF₃N₄O
Molecular Weight:437.21

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antibacterial agent 328 Chemical Structure

CAS. Nr.: 2670430-25-6

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Antibacterial agent 328 (compound 5l) exhibits favorable safety profiles in HepG2 and THP1 cell lines, with selectivity indices of 23.24 and 13.06, respectively^[1].
Antibacterial agent 328 (0.5-1 μg/mL; 15 d) inhibits the growth of isoniazid-resistant, rifampicin-resistant, and multidrug-resistant Mycobacterium tuberculosis strains^[1].
Antibacterial agent 328 exhibits favorable in silico pharmacokinetic properties and druggability, with no violations of the Rule of Five, and its lipophilicity, solubility and molecular size parameters all meet the required criteria^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

INH-resistant, rifampicin-resistant, and multidrug-resistant Mycobacterium tuberculosis
Concentration:

0.5 μg/mL,1 μg/mL
Incubation Time:

15 days
Result:

Showed MIC₅₀s of 1, 0.5, and 1 μg/mL respectively.

Chemical Information

CAS. Nr. 2670430-25-6
Molecular Weight 437.21
Formel C₁₈H₁₂BrF₃N₄O
SMILES

O=C(N/N=C/C1=CC=C(N2N=CC(Br)=C2)C=C1)C3=CC=C(C(F)(F)F)C=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Kumar P, et al. Structure-activity relationship-driven lead optimization of pyrazole hydrazide-hydrazone analogues as potent antimycobacterial agents: in vitro and in silico studies. Bioorg Med Chem Lett. Published online February 26, 2026. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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