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Art. -Nr.: HY-129286

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ASN 05397535

ASN 05397535 is an anticancer agent. ASN 05397535 can be used in the research of colon adenocarcinoma and prostate cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 601502-36-7
Formel: C₂₁H₁₆ClN₃O₃
Molecular Weight:393.83

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

ASN 05397535 Chemical Structure

CAS. Nr.: 601502-36-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

ASN 05397535 is an anticancer agent. ASN 05397535 can be used in the research of colon adenocarcinoma and prostate cancer^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	GI₅₀	<1 μM Compound: 49	Cytotoxicity in HEK293 cells assessed as growth inhibition measured after 48 hrs by MTT assay Cytotoxicity in HEK293 cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 27153347]
LNCaP	GI₅₀	<1 μM Compound: 49	Cytotoxicity in human LNCAP cells assessed as growth inhibition measured after 48 hrs by MTT assay Cytotoxicity in human LNCAP cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 27153347]
MDA-MB-231	GI₅₀	<1 μM Compound: 49	Cytotoxicity in human MDA-MB-231 cells assessed as growth inhibition measured after 48 hrs by MTT assay Cytotoxicity in human MDA-MB-231 cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 27153347]
U-937	GI₅₀	<1 μM Compound: 49	Cytotoxicity in human U937 cells assessed as growth inhibition measured after 48 hrs by MTT assay Cytotoxicity in human U937 cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 27153347]

In Vitro

ASN 05397535 exhibits almost no direct inhibitory activity against the ATP-binding sites of Aurora-A and Aurora-B^[1].
ASN 05397535 (10 μM) exhibits inhibitory activity against DU145 and HT-29, with GI₅₀ values of 32.95 μM and 1.03 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 601502-36-7
Molecular Weight 393.83
Formel C₂₁H₁₆ClN₃O₃
SMILES

ClC=1C=CC2=NC(C=3C=CC=CC3O)=C(NCC4=CC=C5OCOC5=C4)N2C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Morshed MN. Identification of Aurora-A Inhibitors by Ligand and Structure-Based Virtual Screening. Mol Inform. 2014 May;33(5):369-81.
[Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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