35115-62-9
Chemical Structure
SQ 20858
- CAS. Nr.: 35115-62-9
- Formula:C57H77N15O14
- Molecular Weight:1196.31
IUPAC Name: ((S)-5-oxopyrrolidine-2-carbonyl)-L-asparaginyl-L-tryptophyl-L-prolyl-L-histidyl-L-prolyl-L-glutaminyl-L-isoleucyl-L-prolyl-L-proline
InChIKey: FCNFVZKCSNGFBQ-UIABVJAASA-N
SMILES: O=C(N1[C@@H](CCC1)C(N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N4[C@@H](CCC4)C(N5[C@@H](CCC5)C(O)=O)=O)=O)=O)=O)=O)=O)[C@@H](NC([C@H](CC(N)=O)NC([C@@H]6CCC(N6)=O)=O)=O)CC7=CNC8=CC=CC=C78
Biological Activity: SQ 20858 is a competitive Angiotensin-converting enzyme inhibitor. SQ 20858 blocks the conversion of Angiotensin I to Angiotensin II, inhibits the inactivation of Bradykinin (HY-P0206) and amplifies the hypotensive response of Bradykinin. SQ 20858 blocks the pressor responses of Angiotensin I and rabbit Renin, but has no effect on the pressor effect of angiotensin II . SQ 20858 reduces blood pressure in renal hypertension models. SQ 20858 can be used in studies related to chronic renal hypertension[1][2][3].
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SQ 20858 | SQ 20858 is a competitive Angiotensin-converting enzyme inhibitor. SQ 20858 blocks the conversion of Angiotensin I to Angiotensin II, inhibits the inactivation of Bradykinin (HY-P0206) and amplifies the hypotensive response of Bradykinin. SQ 20858 blocks the pressor responses of Angiotensin I and rabbit Renin, but has no effect on the pressor effect of angiotensin II . SQ 20858 reduces blood pressure in renal hypertension models. SQ 20858 can be used in studies related to chronic renal hypertension. | |||||||||||||||||||||
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- [1]. Loyke H F. Dose response of SQ 20,858 in chronic renal hypertension[J]. Pharmacological Research Communications, 1977, 9(2): 181-186. [Content Brief]
- [2]. Romero JC, et al. Effect of blockade of angiotensin-I converting enzyme on the blood pressure of renal hypertensive rabbits. Cardiovasc Res. 1974 Sep;8(5):681-7. [Content Brief]
- [3]. Murthy VS, et al. Inhibition of angiotensin converting enzyme by SQ 14,225 in conscious rabbits. European journal of pharmacology. 1977 Dec 01;46(3):207-12. [Content Brief]
Keywords
