521076-75-5
Chemical Structure
NLS peptide
- CAS. Nr.: 521076-75-5
- Formula:C53H98N20O14S
- Molecular Weight:1271.54
InChIKey: PYLFVKZYEXYELQ-KKMVKRJBSA-N
SMILES: O=C(NCC(NCC(NCC(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(NCC(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CS)N
Biological Activity: NLS peptide is a nuclear localization signal peptide, a short amino acid sequence that can be recognized by nuclear transport machinery (such as the Importin protein complex). NLS peptide can directionally transport the molecules or nanoparticles linked to it into the nucleus, and the N-terminal Cys terminus can be used for subsequent coupling. NLS peptide can be used to construct nucleus-specific imaging probes and nucleus-targeted nanoparticles[1][2]
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NLS peptide | NLS peptide is a nuclear localization signal peptide, a short amino acid sequence that can be recognized by nuclear transport machinery (such as the Importin protein complex). NLS peptide can directionally transport the molecules or nanoparticles linked to it into the nucleus, and the N-terminal Cys terminus can be used for subsequent coupling. NLS peptide can be used to construct nucleus-specific imaging probes and nucleus-targeted nanoparticles | |||||||||||||||||||||
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- [1]. Ali MRK, et al. Nuclear Membrane-Targeted Gold Nanoparticles Inhibit Cancer Cell Migration and Invasion. ACS Nano. 2017;11(4):3716-3726. [Content Brief]
- [2]. Nitin N, et al. NLS peptide conjugated molecular beacons for visualizing nuclear RNA in living cells. Bioconjug Chem. 2008;19(11):2205-2211. [Content Brief]
Keywords
