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Art. -Nr.: HY-175167

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diABZI-i

diABZI-i is an orthogonal STING inhibitor. diABZI-i significantly inhibits cGAMP-induced IFNβ in PBMCs. diABZI-i also activates constitutive signaling of V155M SAVI and exerts potent agonistic effects in the STING V155M THP-1 cell model. diABZI-i can be used for research on monogenic autoinflammatory diseases such as SAVI.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₄₅H₅₀N₁₂O₆
Molecular Weight:854.96

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

diABZI-i Chemical Structure

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

diABZI-i (1.3 nM-50 μM; 24 h) potently inhibits cGAMP-induced β-interferon production in human peripheral blood mononuclear cells (PBMCs), with an IC₅₀ of 49 nM^[1].
diABZI-i inhibits the cGAMP-induced interferon signaling pathway in wild-type THP-1 cells, with an IC₅₀ of 3 μM and a maximum inhibition rate >95%^[1].
diABZI-i potently activates the constitutive interferon signaling pathway in STING^V155M-mutant THP-1 cells, with an EC₅₀ of 17 nM, rather than inhibiting this signaling pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 854.96
Formel C₄₅H₅₀N₁₂O₆
SMILES

CCN1N=CC=C1C(/N=C2N(C3=C(N\2C/C(C)=C(CN4C5=C(C=C(C=C5N(/C4=N\C(C6=CC(C)=NN6CC)=O)C)C(N)=O)OCC7=CC=CC(OC)=C7)\C)C=CC(C(N)=O)=C3)C)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Xie T, et al. Orthosteric STING inhibition elucidates molecular correction of SAVI STING. Nat Commun. 2025;16(1):5695. Published 2025 Jul 1. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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