Pdgfb - platelet derived growth factor subunit B Gene

Also Known as SIS; c-sis

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24628

Summary

Enables signaling receptor binding activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of cell migration; and response to peptide hormone. Located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Used to study asthma; brain infarction; glomerulonephritis; and visual epilepsy. Biomarker of cholestasis; hypertension (multiple); liver cirrhosis; oligohydramnios; and ureteral obstruction. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue Cancer (multiple); familial meningioma; and prostatic hypertrophy. Orthologous to human PDGFB (platelet derived growth factor subunit B). [provided by Alliance of Genome Resources, Apr 2022]

Pdgfb Products (2)

mRNA Protein Name
NM_031524.1 NP_113712.1 platelet-derived growth factor subunit B precursor
NM_031524.1 NP_113712.1 platelet-derived growth factor subunit B precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables signaling receptor binding IMP
IMP: Inferred from mutant phenotype
16014047 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to angiotensin IEP
IEP: Inferred from expression pattern
10506481 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
7653578 RGD
involved in cellular response to mycophenolic acid IDA
IDA: Inferred from direct assay
18723570 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
11870082 RGD
involved in myoblast proliferation IEP
IEP: Inferred from expression pattern
2425941 RGD
involved in platelet-derived growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17449016 RGD
involved in positive regulation of DNA replication IMP
IMP: Inferred from mutant phenotype
12084843 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18723570 RGD
involved in positive regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
19460854 RGD
involved in positive regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
15358192 RGD
involved in positive regulation of hepatic stellate cell activation IMP
IMP: Inferred from mutant phenotype
15358192 RGD
involved in positive regulation of hepatic stellate cell proliferation IMP
IMP: Inferred from mutant phenotype
15358192 RGD
involved in positive regulation of metanephric mesenchymal cell migration IDA
IDA: Inferred from direct assay
19460854 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
17449016 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
17449016 RGD
involved in regulation of cell population proliferation IEP
IEP: Inferred from expression pattern
7758166 RGD
involved in response to axon injury IEP
IEP: Inferred from expression pattern
7922556 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
14724432 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
14724432 RGD
involved in response to human chorionic gonadotropin IEP
IEP: Inferred from expression pattern
17108335 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
8447423 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
12606528 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16156274 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16156274 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
10550325 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
10550325 RGD
located in dendrite IDA
IDA: Inferred from direct assay
14980813 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
9072322 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
7922556 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

platelet-derived growth factor subunit B

  • PDGF subunit B

  • PDGF-2

  • Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis)

  • pdgf protein

  • platelet derived growth factor, B polypeptide

  • platelet derived growth factor-bb

  • platelet-derived growth factor B chain

  • p

Recombinant Pdgfb Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P7278 PDGF-BB Protein, Rat Q05028 (S74-T182) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7278A PDGF-BB Protein, Rat (His) Q05028 (S74-T182) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P991724 Vasigrobart Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-159059 Ganoderma lucidum polysaccharide 41.20% Unkown
HY-160047 AX102 sodium 98.15% Unkown
HY-RS17147 Pdgfb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-160048 PEG40K unconjugated/naked AX102 sodium / Unkown
HY-RS10251 PDGFB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174552 Human PDGFB mRNA / Unkown
HY-RS23596 Pdgfb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdgfb NCBI NCBI:5155