Map3k13 - mitogen-activated protein kinase kinase kinase 13 Gene

Also Known as LZK; C130026N12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 71751

Summary

Predicted to enable several functions, including IkappaB kinase complex binding activity; JUN kinase kinase kinase activity; and protein homodimerization activity. Involved in several processes, including positive regulation of JUN kinase activity; positive regulation of branching morphogenesis of a nerve; and positive regulation of cell projection organization. Predicted to be located in membrane. Is expressed in diencephalon lateral wall mantle layer; dorsal grey horn; late tubule; midbrain mantle layer; and ureter. Orthologous to human MAP3K13 (mitogen-activated protein kinase kinase kinase 13). [provided by Alliance of Genome Resources, Apr 2022]

Map3k13 Products (1)

mRNA Protein Name
NM_172821.3 NP_766409.2 mitogen-activated protein kinase kinase kinase 13

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables protein serine/threonine kinase activator activity IMP
IMP: Inferred from mutant phenotype
27511108 MGI
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
27511108 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in JNK cascade IMP
IMP: Inferred from mutant phenotype
27511108 MGI
involved in peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
27511108 MGI
involved in positive regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
27511108 MGI
involved in positive regulation of axon extension IMP
IMP: Inferred from mutant phenotype
27511108 MGI
involved in positive regulation of branching morphogenesis of a nerve IMP
IMP: Inferred from mutant phenotype
27511108 MGI
involved in positive regulation of neuron maturation IMP
IMP: Inferred from mutant phenotype
27511108 MGI
involved in positive regulation of neuron projection arborization IMP
IMP: Inferred from mutant phenotype
27511108 MGI
involved in positive regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
27511108 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 13

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-170595 PROTAC LZK degrader 1 / Unkown
HY-RS08050 MAP3K13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21245 Map3k13 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27762 Map3k13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map3k13 NCBI NCBI:9175