MAP3K13 - mitogen-activated protein kinase kinase kinase 13 Gene

Homo sapiens

Also known as LZK; MLK; MEKK13

Gene ID: 9175 | Gene type: protein coding

About MAP3K13

Cytogenetic location: 3q27.2 Genomic coordinates (GRCh38): 3:185,282,961-185,489,094 (from NCBI)

This gene has 15 transcripts (splice variants), 199 orthologues, 23 paralogues and is associated with 94 phenotypes. Ubiquitous expression in adrenal (RPKM 3.8), kidney (RPKM 3.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]

MAP3K13 Products(3)

mRNA	Protein	Name
NM_001242314.2	NP_001229243.1	mitogen-activated protein kinase kinase kinase 13 isoform 1
NM_001242317.2	NP_001229246.1	mitogen-activated protein kinase kinase kinase 13 isoform 2
NM_004721.5	NP_004712.1	mitogen-activated protein kinase kinase kinase 13 isoform 1

MAP3K13 Protein Structure

Pkinase_Tyr

0
200
400
600
800
966 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 13

leucine zipper-bearing kinase

Related Diseases

Diseases

Alias

Carotid Body Cancer

Cancer Of Carotid Body	Malignant Carotid Body Paraganglioma
Malignant Carotid Body Tumor	Malignant Neoplasm Of Carotid Body

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08050	MAP3K13 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MAP3K13	VGNC	VGNC:31191
Felis catus	MAP3K13	VGNC	VGNC:68158
Rattus norvegicus	MAP3K13	RGD	RGD:1561227
Mus musculus	MAP3K13	MGD	MGI:2444243
Canis familiaris	MAP3K13	VGNC	VGNC:42969
Macaca mulatta	MAP3K13	VGNC	VGNC:74494

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