GLO1 - glyoxalase I Gene

Also Known as GLYI; GLOD1; HEL-S-74

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2739

About GLO1

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:38,675,925-38,703,145 (from NCBI)

This gene has 2 transcripts (splice variants), 262 orthologues and 1 paralogue. Ubiquitous expression in prostate (RPKM 115.6), duodenum (RPKM 59.9) and 24 other tissues.

Summary

The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]

GLO1 Products (1)

mRNA	Protein	Name
NM_006708.3	NP_006699.2	lactoylglutathione lyase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables lactoylglutathione lyase activity	IDA IDA: Inferred from direct assay	9705294	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	9705294	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	11489834	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10807791	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLO1 Protein Structure

Glyoxalase

0
100
184 a.a.

Protein Preferred Names	Protein Names
lactoylglutathione lyase	S-D-lactoylglutathione methylglyoxal lyase aldoketomutase epididymis secretory protein Li 74 glx I glyoxalase domain containing 1 ketone-aldehyde mutase lactoyl glutathione lyase methylglyoxalase

GLO1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	GLO1	Q04760	PUS10	Homo sapiens	Q3MIT2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

GLO1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80942	GLO1 Antibody (YA413)	WB, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Diabetes Mellitus	Diabetes
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
Hyperglycemia
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-136684	BrBzGCp2	Inhibitor	99.00%	Unkown
HY-185057	S-D-Lactoylglutathione	Substrate	98.88%	Unkown
HY-34005	2-Dimethylaminophenol	Inhibitor	/	Unkown
HY-146655	Glyoxalase I inhibitor 3	Inhibitor	98.06%	Unkown
HY-124824	Methyl gerfelin	Inhibitor	99.9%	Unkown
HY-146653	Glyoxalase I inhibitor 1	Inhibitor	/	Unkown
HY-146654	Glyoxalase I inhibitor 2	Inhibitor	/	Unkown
HY-146657	4BAB	Inhibitor	/	Unkown
HY-RS05485	GLO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05486	Glo1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05487	Glo1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GLO1	RGD	RGD:2702
Mus musculus	GLO1	MGD	MGI:95742
Canis familiaris	GLO1	VGNC	VGNC:54950
Macaca mulatta	GLO1	VGNC	VGNC:81071
Bos taurus	GLO1	VGNC	VGNC:50185
Felis catus	GLO1	VGNC	VGNC:62584
Others	GLO1	NCBI