SMC4 - structural maintenance of chromosomes 4 Gene

Also Known as CAPC; CAP-C; SMC-4; SMC4L1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10051

About SMC4

Cytogenetic location: 3q25.33 Genomic coordinates (GRCh38): 3:160,399,650-160,434,953 (from NCBI)

This gene has 27 transcripts (splice variants), 214 orthologues and 7 paralogues. Broad expression in testis (RPKM 22.9), bone marrow (RPKM 22.6) and 24 other tissues.

Summary

This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2. [provided by RefSeq, Jun 2016]

SMC4 Products (3)

mRNA Protein Name
NM_001002800.3 NP_001002800.1 structural maintenance of chromosomes protein 4 isoform 1
NM_001288753.2 NP_001275682.1 structural maintenance of chromosomes protein 4 isoform 2
NM_005496.3 NP_005487.3 structural maintenance of chromosomes protein 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9789013 GOA
Biological Process GO Annotation Evidence References Source
involved in mitotic chromosome condensation IDA
IDA: Inferred from direct assay
11136719 GOA
involved in positive regulation of chromosome condensation IDA
IDA: Inferred from direct assay
17268547 GOA
Cellular Component GO Annotation Evidence References Source
part of condensin complex IDA
IDA: Inferred from direct assay
9789013 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMC4 Protein Structure

SMC_N

SMC_N: RecF/RecN/SMC N terminal domain (83 - 1270)

SMC_hinge

SMC_hinge: SMC proteins Flexible Hinge Domain (613 - 728)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1288 a.a.
Protein Preferred Names Protein Names

structural maintenance of chromosomes protein 4

  • SMC protein 4

SMC4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SMC4 Q9NTJ3 NCAPH2 Homo sapiens Q6IBW4
Anti Bait CoIP
17268547
Intra
SMC4 Q9NTJ3 SMC2 Homo sapiens O95347
Crosslink
30021884
Cross: Cross-species interaction Intra: Intraspecies interaction

SMC4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82595 SMC4 Antibody (YA2340) WB, ICC/IF, FC Human, Mouse

Related Diseases

Diseases Alias
Pleural Empyema

  • Empyema

  • Pyothorax

  • Empyema, Pleural

  • Abscess Of Pleural Cavity

  • Abscess Of Thorax

  • Empyema Of Pleura

  • Empyema Of Pleura Without Fistula

  • Empyema With Fistula

  • Empyema With No Fistula

  • Empyema With Pleural Fistula

  • Empyema Without Mention Of Fistula

  • Empyema, Chest

  • Lung Empyema

  • Pleural Empyema With Fistula

  • Pleural Empyema With No Fistula

  • Purulent Pleurisy

  • Purulent Pleuritis

  • Thorax Abscess

  • Pyopneumothorax
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Cornelia De Lange Syndrome

  • De Lange Syndrome

  • Brachmann De Lange Syndrome

  • Brachmann-De Lange Syndrome

  • Cdls

  • Bdls

  • Typus Degenerativus Amstelodamensis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13420 SMC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20820 Smc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27334 Smc4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SMC4 VGNC VGNC:65478
Canis familiaris SMC4 VGNC VGNC:46545
Macaca mulatta SMC4 VGNC VGNC:77699
Mus musculus SMC4 MGD MGI:1917349
Rattus norvegicus SMC4 RGD RGD:1306680
Bos taurus SMC4 VGNC VGNC:35001
Others SMC4 NCBI