SMC2 - structural maintenance of chromosomes 2 Gene

Also Known as CAPE; CAP-E; SMC-2; SMC2L1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10592

About SMC2

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:104,088,263-104,141,419 (from NCBI)

This gene has 5 transcripts (splice variants), 219 orthologues and 7 paralogues. Ubiquitous expression in lymph node (RPKM 6.5), testis (RPKM 6.0) and 24 other tissues.

Summary

Predicted to enable ATP binding activity; chromatin binding activity; and single-stranded DNA binding activity. Involved in mitotic chromosome condensation. Located in condensed chromosome; cytoplasm; and nuclear lumen. Part of condensin complex. [provided by Alliance of Genome Resources, Apr 2022]

SMC2 Products (4)

mRNA	Protein	Name
NM_001042550.2	NP_001036015.1	structural maintenance of chromosomes protein 2
NM_001042551.2	NP_001036016.1	structural maintenance of chromosomes protein 2
NM_001265602.2	NP_001252531.1	structural maintenance of chromosomes protein 2
NM_006444.3	NP_006435.2	structural maintenance of chromosomes protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9789013	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitotic chromosome condensation	IDA IDA: Inferred from direct assay	11136719	GOA
involved in positive regulation of chromosome condensation	IDA IDA: Inferred from direct assay	17268547	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in condensed chromosome	IDA IDA: Inferred from direct assay	12589063	GOA
part of condensin complex	IDA IDA: Inferred from direct assay	9789013	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10958694	GOA
located in nuclear chromosome	IDA IDA: Inferred from direct assay	10958694	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12589063	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMC2 Protein Structure

SMC_N

SMC_hinge

SMC_N

0
200
400
600
800
1000
1197 a.a.

Protein Preferred Names	Protein Names
structural maintenance of chromosomes protein 2	SMC protein 2

SMC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SMC2	O95347	NCAPH	Homo sapiens	Q15003	Anti Bait CoIP	21633354
Intra	SMC2	O95347	SMC4	Homo sapiens	Q9NTJ3	Anti Bait CoIP	17113138
Intra	SMC2	O95347	SMC4	Homo sapiens	Q9NTJ3	Anti Bait CoIP	17268547

Cross: Cross-species interaction Intra: Intraspecies interaction

SMC2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87076	SMC2 Antibody (YA6769)	WB, IHC-P, ICC/IF	Human, Monkey

Related Diseases

Diseases	Alias
Pleural Empyema	Empyema Pyothorax Empyema, Pleural Abscess Of Pleural Cavity Abscess Of Thorax Empyema Of Pleura Empyema Of Pleura Without Fistula Empyema With Fistula Empyema With No Fistula Empyema With Pleural Fistula Empyema Without Mention Of Fistula Empyema, Chest Lung Empyema Pleural Empyema With Fistula Pleural Empyema With No Fistula Purulent Pleurisy Purulent Pleuritis Thorax Abscess Pyopneumothorax

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11547	RAB33B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13418	SMC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SMC2	VGNC	VGNC:34999
Mus musculus	SMC2	MGD	MGI:106067
Rattus norvegicus	SMC2	RGD	RGD:1305227
Macaca mulatta	SMC2	VGNC	VGNC:77698
Canis familiaris	SMC2	VGNC	VGNC:46543
Felis catus	SMC2	VGNC	VGNC:65476
Others	SMC2	NCBI