LZK Antibody (YA10052)
(Synonyms: LZK, MAP3K13, Mitogen-activated protein kinase kinase kinase 13, Leucine zipper-bearing kinase, Mixed lineage kinase, MLK)LZK Antibody (YA10052) is a Mouse-derived and non-conjugated IgM Monoclonal antibody, targeting to LZK.
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Host:
Mouse
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Isotype:
IgM
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Application:
WB, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:10-50 |
Product Details
LZK Antibody (YA10052) is a Mouse-derived and non-conjugated IgM Monoclonal antibody, targeting to LZK.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 108 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 108 kDa
Purified recombinant protein of human LZK.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgM
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
LZK activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B
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Subcellular Localization
Cytoplasm; Membrane
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Expression
Tissue_Specificity: Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas. -
Isoforms & Post-Translational Modification
LZK has 5 isoforms, O43283-1: amino acid length is 966, molecular weight is 108296 Da (predicted); O43283-3: amino acid length is 160, molecular weight is 17575 Da (predicted); O43283-4: amino acid length is 822, molecular weight is 92654 Da (predicted); O43283-5: amino acid length is 759, molecular weight is 85404 Da (predicted); O43283-6: amino acid length is 128, molecular weight is 14073 Da (predicted).Autophosphorylated on serine and threonine residues
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Subunit
Homodimer; forms dimers through the leucine-zipper motif.
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SwissProt ID
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Synonyms
LZK, MAP3K13, Mitogen-activated protein kinase kinase kinase 13, Leucine zipper-bearing kinase, Mixed lineage kinase, MLK
Documentation
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