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Art. -Nr.: HY-103577

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LG-121071

LG-121071 is an orally active and selective androgen receptor modulator with a K_i of 17 nM.

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CAS. Nr.: 179897-70-2
Formel: C₁₅H₁₅F₃N₂O
Molecular Weight:296.29

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

LG-121071 Chemical Structure

CAS. Nr.: 179897-70-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

LG-121071 is an orally active and selective androgen receptor modulator with a K_i of 17 nM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CV-1	EC₅₀	4 nM Compound: 4	Agonist activity to the human androgen receptor (hAR) in CV-1 cells Agonist activity to the human androgen receptor (hAR) in CV-1 cells	[PMID: 10340624]
CV-1	IC₅₀	4580 nM Compound: 4	Antagonistic activity against human androgen receptor (hAR) in CV-1 cells using cotransfection assay Antagonistic activity against human androgen receptor (hAR) in CV-1 cells using cotransfection assay	[PMID: 10340624]
CV-1	EC₅₀	4.1 nM Compound: 3c, LG121071	Agonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assay Agonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assay	[PMID: 17439112]
CV-1	IC₅₀	>10000 nM Compound: 3c, LG121071	Antagonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assay Antagonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assay	[PMID: 17439112]
CV-1	EC₅₀	4 nM Compound: 8	Agonist activity against Human Androgen receptor expressed in CV-1 cells Agonist activity against Human Androgen receptor expressed in CV-1 cells	[PMID: 9925725]
CV-1	IC₅₀	7481 nM Compound: 8	Antagonist activity against Human Androgen receptor expressed in CV-1 cells Antagonist activity against Human Androgen receptor expressed in CV-1 cells	[PMID: 9925725]

Chemical Information

CAS. Nr. 179897-70-2
Molecular Weight 296.29
Formel C₁₅H₁₅F₃N₂O
SMILES

O=C1NC2=C(C=C(C(CC)CCN3)C3=C2)C(C(F)(F)F)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Knoop A, et al. In vitro metabolism studies on the selective androgen receptor modulator (SARM) LG121071 and its implementation into human doping controls using liquid chromatography-mass spectrometry. Eur J Mass Spectrom (Chichester). 2015;21(1):27-36. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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