Neuroprotective agent 1
Neuroprotective agent 1 (2), a promising neuroprotective agent for the study of ischemic stroke, shows promising neuroprotective activity with the EC50 value of 16.07 μM in the model of glutamate-induced excitotoxicity and 19.30 μM in the model of H2O2-induced oxidative damage.
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- CAS. Nr.: 2344786-13-4
- Formel: C32H31NO7
- Molecular Weight:541.59
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PC-12 | EC50 |
16.07 μM
Compound: 2
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Neuroprotective activity against glutamate induced excitotoxicity in rat PC12 cells pretreated with glutamate for 24 hrs followed by compound addition and measured after 24 hrs
Neuroprotective activity against glutamate induced excitotoxicity in rat PC12 cells pretreated with glutamate for 24 hrs followed by compound addition and measured after 24 hrs
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[PMID: 36921528] |
| PC-12 | EC50 |
19.3 μM
Compound: 2
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Neuroprotective activity against H2O2-induced oxidative damage in rat PC12 cells pretreated with H2O2 for 24 hrs followed by compound addition and measured after 24 hrs
Neuroprotective activity against H2O2-induced oxidative damage in rat PC12 cells pretreated with H2O2 for 24 hrs followed by compound addition and measured after 24 hrs
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[PMID: 36921528] |
| PC-12 | IC50 |
3.3 μM
Compound: 2
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Cytotoxicity against rat PC12 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against rat PC12 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
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[PMID: 36921528] |
Chemical Information
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CAS. Nr. 2344786-13-4
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Molecular Weight 541.59
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Formel C32H31NO7
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SMILES
O=C(N(C)C1=CC=CC=C1)OC(C=C2OC3=C4C(O)=C5C=CC(C)(C)OC5=C3)=C(OC)C(C/C=C(C)\C)=C2C4=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Neuroprotective agent 1 Related Classifications
HY-149094 Related Classifications
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