P-gp-IN-32
P-gp-IN-32 is a P-glycoprotein (P-gp) inhibitor. P-gp-IN-32 exhibits low cytotoxicity and potent multidrug resistance (MDR) reversal activity against Doxorubicin (HY-15142A) in MCF7/ADR cells (IC50 = 0.11 μM, reversal fold (RF) = 215.9). P-gp-IN-32 can bind to P-gp directly, induce a conformation change of P-gp and inhibit the efflux function. P-gp-IN-32 can be used for the research of cancer, such as breast cancer.
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- CAS. Nr.: 2918249-59-7
- Formel: C35H34N2O5
- Molecular Weight:562.65
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
P-gp-IN-32 (Compound BP3p) (5 μM) shows growth inhibition rates below 25% in both MCF-7 and MCF-7/ADR cells[1].
P-gp-IN-32 has a RF of 215.9 combined with Doxorubicin (HY-15142A) (IC50 of 0.11 μM) in MCF-7/ADR cells[1].
P-gp-IN-32 (2.5-5 μM, 4 h) increases Rhodamine 123 accumulation in MCF-7/ADR cells in a dose-dependent manner[1].
P-gp-IN-32 (0.5-5 μM, 48 h) has no significant effect on P-gp expression in MCF-7/ADR cells[1].
P-gp-IN-32 (50 μM) enhances UIC-2 antibody (HY-P990196) binding to P-gp in MCF-7/ADR cells[1].
P-gp-IN-32 (5 μM, 5 days) reduces the volume of MCF-7/ADR 3D tumor spheroids combined with Doxorubicin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7/ADR cells
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Concentration:0.5, 2.5 and 5 μM
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Incubation Time:48 h
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Result:Did not reduce P-gp expression.
Chemical Information
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CAS. Nr. 2918249-59-7
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Molecular Weight 562.65
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Formel C35H34N2O5
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SMILES
COC1=CC(C2=CC3=C(N(C(C(N4CCC5=C(C4)C=C(C(OC)=C5)OC)=O)=C3)CC6=CC=C(C=C6)OC)C=C2)=CC=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
P-gp-IN-32 Related Classifications
HY-175838 Related Classifications
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