Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) 

Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) is an anti-monkey/human MDR-1/CD243 IgG2a monoclonal antibody. Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) can efficiently inhibit P-glycoprotein. Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) enhances the inhibitory effect on multidrug resistance (MDR) by suppressing drug efflux. Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) can be used for research on cancer^[1][2].

Mouse IgG2a kappa

Mouse IgG2a kappa, Isotype Control

Human/Monkey

MDR-1/CD243

Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) (0-80 μg/mL, 30 min) significantly increases the inhibitory effect of P-glycoprotein (Pgp) and enhances the accumulation of subsequent intracellular drugs combined with ACT positive modulators (such as Cyclosporine A (CsA) (HY-B0579), SDZ PSC 833 (HY-17384)) in NIH 3T3 MDR1 cells^[1].
Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) (20 μg/mL, 30 min) significantly inhibits the efflux of Rh123 (HY-D0816) and Doxorubicin (HY-15142A) from MDR cells^[2].
Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) (20 μg/mL, 30 min) enhances the cytotoxicity of Vinblastine (HY-13780) in BALB/c 3T3-1000 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) (5 mg/kg, i.v., single dose, 4 hours before administering Daunorubicin (HY-13062A)) significantly increases the accumulation of Daunorubicin in Pgp positive tumors combined with CsA in SCID mice bearing tumors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5243  [NCBI]

P08183

in vivo MDR-1 blocking/depletion in xenogeneic murinetumor models; in vitro MDR-1 blocking; Immuno

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2)]

Shipping with dry ice.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

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• [1]. Goda K, et al. Complete inhibition of P-glycoprotein by simultaneous treatment with a distinct class of modulators and the UIC2 monoclonal antibody. J Pharmacol Exp Ther. 2007 Jan;320(1):81-8.  [Content Brief]

  [2]. Mechetner EB, et al. Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5824-8.  [Content Brief]