Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2)
Based on 1 Customer Validation
Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) is an anti-monkey/human MDR-1/CD243 IgG2a monoclonal antibody. Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) can efficiently inhibit P-glycoprotein. Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) enhances the inhibitory effect on multidrug resistance (MDR) by suppressing drug efflux. Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) can be used for research on cancer.
For research use only. We do not sell to patients.
- Purity: 97.85%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Mouse IgG2a kappa
Human/Monkey
MDR-1/CD243
Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) (0-80 μg/mL, 30 min) significantly increases the inhibitory effect of P-glycoprotein (Pgp) and enhances the accumulation of subsequent intracellular drugs combined with ACT positive modulators (such as Cyclosporine A (CsA) (HY-B0579), SDZ PSC 833 (HY-17384)) in NIH 3T3 MDR1 cells[1].
Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) (20 μg/mL, 30 min) significantly inhibits the efflux of Rh123 (HY-D0816) and Doxorubicin (HY-15142A) from MDR cells[2].
Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) (20 μg/mL, 30 min) enhances the cytotoxicity of Vinblastine (HY-13780) in BALB/c 3T3-1000 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BALB/c 3T3-1000 cells
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Concentration:20 μg/mL
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Incubation Time:30 min
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Result:Reduced the ID50 of Vinblastine from 650 ng/mL to 150 ng/mL.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4×106 NIH 3T3 MDR1 cells injected SCID mice (10-12 weeks)[1]
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Dosage:5 mg/kg, combinated with CsA (10 mg/kg, i.p.)
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Administration:Intravenous injection (i.v.), single dose, 4 hours before administering Daunorubicin (5 mg/kg, i.v.)
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Result:Significantly increased the drug content of Daunorubicin in tumors.
P08183
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo MDR-1 blocking/depletion in xenogeneic murinetumor models; in vitro MDR-1 blocking; Immuno
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2)]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Goda K, et al. Complete inhibition of P-glycoprotein by simultaneous treatment with a distinct class of modulators and the UIC2 monoclonal antibody. J Pharmacol Exp Ther. 2007 Jan;320(1):81-8. [Content Brief]
[2]. Mechetner EB, et al. Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5824-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) Related Classifications
HY-P990196 Related Classifications
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