PF-6870961
PF-6870961 is an inverse agonist of GHSR1a with Ki values of 73.6 nM (human GHSR), 239 nM (rat GHSR), and 217 nM (dog GHSR), respectively. PF-6870961 inhibits the constitutive GHSR1a-induced IP accumulation with an IC50 value of 300 nM. PF-6870961 also inhibits constitutive GHSR1a β-arrestin mobilization with an IC50 value of 1.10 nM.
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- CAS. Nr.: 2857112-06-0
- Formel: C29H32N6O2S
- Molecular Weight:528.67
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Satiated and fasted rats model[1]
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Dosage:2.5 mg/kg, 10 mg/kg, and 40 mg/kg
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Administration:Intraperitoneal injection
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Result:Significantly reduced food intake at 40 mg/kg.
Chemical Information
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CAS. Nr. 2857112-06-0
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Molecular Weight 528.67
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Formel C29H32N6O2S
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SMILES
CC1=CN(C(S1)=N2)C=C2CC(N3CCC4(CC3)CN([C@H]5C6=CC=C(C7=NC(O)=NC(C)=C7)C=C6CC5)C4)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PF-6870961 Related Classifications
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