Synthesis of a novel series of fluoroarene derivatives of artemisinin as potent antifungal and anticancer agent

  • Bioorg Med Chem Lett. 2015 Aug 15;25(16):3338-41. doi: 10.1016/j.bmcl.2015.05.067.
Pori Buragohain  1 ,  Naresh Surineni  1 ,  Nabin C Barua  2 ,  Purnajyoti D Bhuyan  1 ,  Paran Boruah  1 ,  Jagat C Borah  3 ,  Surbala Laisharm  3 ,  Dinesh Singh Moirangthem  3
Affiliations
  • 1. CSIR-North East Institute of Science and Technology, Jorhat 785006, Assam, India.
  • 2. CSIR-North East Institute of Science and Technology, Jorhat 785006, Assam, India. Electronic address: [email protected].
  • 3. Institute of Bioresources and Sustainable Development, Takyelpat, Imphal 795001, Manipur, India.
PMID: 26099535 DOI: 10.1016/j.bmcl.2015.05.067
Abstract

A series of new fluoroarene derivatives of artemisinin were prepared using Suzuki and Sonogashira cross-coupling reactions. An Antifungal and antitumor activity was evaluated against opportunistic pathogen Fusarium oxysporum and Hela Cancer cell line. All these derivatives have shown moderate to good activity.

Keywords
Anticancer; Antifungal; Artemisinin; Fusarium oxysporum; Suzuki cross-coupling.