Insights Into the Function and Clinical Application of HDAC5 in Cancer Management

  • Front Oncol. 2021 Jun 10:11:661620. doi: 10.3389/fonc.2021.661620.
Jun Yang  1 ,  Chaoju Gong  2 ,  Qinjian Ke  3 ,  Zejun Fang  3 ,  Xiaowen Chen  4 ,  Ming Ye  5 ,  Xi Xu  6
Affiliations
  • 1. Department of Orthopedic Surgery, Sanmen People's Hospital of Zhejiang Province, Sanmenwan Branch of the First Affiliated Hospital, College of Medicine, Zhejiang University, Sanmen, China.
  • 2. Central Laboratory, The Municipal Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
  • 3. Central Laboratory, Sanmen People's Hospital of Zhejiang Province, Sanmenwan Branch of the First Affiliated Hospital, College of Medicine, Zhejiang University, Sanmen, China.
  • 4. Department of Pathophysiology, Zunyi Medical University, Zunyi, China.
  • 5. Department of General Surgery, Sanmen People's Hospital of Zhejiang Province, Sanmenwan Branch of the First Affiliated Hospital, College of Medicine, Zhejiang University, Sanmen, China.
  • 6. Department of Pathology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
PMID: 34178647 DOI: 10.3389/fonc.2021.661620
Abstract

Histone deacetylase 5 (HDAC5) is a class II HDAC. Aberrant expression of HDAC5 has been observed in multiple Cancer types, and its functions in cell proliferation and invasion, the immune response, and maintenance of stemness have been widely studied. HDAC5 is considered as a reliable therapeutic target for Anticancer drugs. In light of recent findings regarding the role of epigenetic reprogramming in tumorigenesis, in this review, we provide an overview of the expression, biological functions, regulatory mechanisms, and clinical significance of HDAC5 in Cancer.

Keywords
HDAC5; biological function; biomarker; cancer; clinical application.