Translational investigation of tolinapant (ASTX660) in acute myeloid leukemia by integrating clinical, bioinformatic and pharmacological approaches

  • Blood Res. 2025 Dec 30;60(1):67. doi: 10.1007/s44313-025-00117-y.
Keli Lima  1  2  3 ,  Frederico Lisboa Nogueira  4 ,  Catarina Sofia Mateus Reis-Silva  5 ,  Rita de Cássia Cavaglieri  4 ,  Leticia Veras Costa-Lotufo  5 ,  João Agostinho Machado-Neto  5 ,  Eduardo Magalhães Rego  6  7  8
Affiliations
  • 1. Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil. [email protected].
  • 2. Center for Cell Based Therapy, São Paulo Research Foundation, Ribeirão Preto, Brazil. [email protected].
  • 3. Division of Hematology, Faculdade de Medicina of University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 155, São Paulo, SP, CEP 05403-000, Brazil. [email protected].
  • 4. Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil.
  • 5. Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
  • 6. Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil. [email protected].
  • 7. Center for Cell Based Therapy, São Paulo Research Foundation, Ribeirão Preto, Brazil. [email protected].
  • 8. Division of Hematology, Faculdade de Medicina of University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 155, São Paulo, SP, CEP 05403-000, Brazil. [email protected].
PMID: 41469824 DOI: 10.1007/s44313-025-00117-y
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