Isolation and characterization of I5B2, a new phosphorus containing inhibitor of angiotensin I converting enzyme produced by Actinomadura sp

  • J Antibiot (Tokyo). 1984 Sep;37(9):965-9. doi: 10.7164/antibiotics.37.965.
Y Kido ,  T Hamakado ,  M Anno ,  E Miyagawa ,  Y Motoki ,  T Wakamiya ,  T Shiba
PMID: 6094415 DOI: 10.7164/antibiotics.37.965
Abstract

A new inhibitor of angiotensin I converting enzyme, I5B2, was isolated from the culture broth of Actinomadura sp. No. 937ZE-1. This compound contains N-methylvaline, tyrosine and 1-amino-2-(4-hydroxyphenyl)ethylphosphonic acid. The microorganism also produced another inhibitor, I5B1, which is identical with K-4 isolated from Actinomadura sp. as an antihypertensive agent.

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