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Art. -Nr.: HY-169111

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SHP2-IN-32

SHP2-IN-32 (compound C6) is an orally active, allosteric SHP2 inhibitor with an IC₅₀ value of 0.13 nM. SHP2-IN-32 exhibits antitumor activity.

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CAS. Nr.: 3043685-80-6
Formel: C₂₉H₂₇ClN₆O₂S
Molecular Weight:559.08

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SHP2-IN-32 Chemical Structure

CAS. Nr.: 3043685-80-6

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

SHP2-IN-32 (compound C6) is an orally active, allosteric SHP2 inhibitor with an IC₅₀ value of 0.13 nM. SHP2-IN-32 exhibits antitumor activity^[1].

IC₅₀ & Target

IC50:0.13 nM (SHP2)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MV4-11	IC₅₀	3.5 nM Compound: C6	Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK-8 assay	[PMID: 39303516]

Chemical Information

CAS. Nr. 3043685-80-6
Molecular Weight 559.08
Formel C₂₉H₂₇ClN₆O₂S
SMILES

N[C@@H]1C2=C(C=CC=C2)CC13CCN(C4=NC=C(SC5=C(Cl)C(NC(C6=C(O)C=CN=C6)=O)=CC=C5)N=C4)CC3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lv X, et al. Discovery of novel substituted pyridine carboxamide derivatives as potent allosteric SHP2 inhibitors. Eur J Med Chem. 2024 Sep 5;279:116830. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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