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Art. -Nr.: HY-184954

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SIK-IN-6

SIK-IN-6 is a selective SIK3 inhibitor with an IC₅₀ of 15 nM. SIK-IN-6 exerts anticancer activity in acute myeloid leukemia with high MEF2C expression, but does not exhibit significant anticancer activity in acute myeloid leukemia with low MEF2C expression or in ovarian cancer. SIK-IN-6 can be used for the research of acute myeloid leukemia.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₆H₂₄F₂N₄O₃
Molecular Weight:478.49

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

SIK-IN-6 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

SIK3

15 nM (IC₅₀)

SIK1

130 nM (IC₅₀)

SIK2

200 nM (IC₅₀)

Alle Salt-inducible Kinase (SIK) Isoform-spezifische Produkte anzeigen :

In Vitro

SIK-IN-6 (Compound 39) potently inhibits purified SIK3 with an IC₅₀ of 15 nM, and shows weaker inhibition of purified SIK1 (IC₅₀ 130 nM) and SIK2 (IC₅₀ 200 nM), along with favorable in vitro ADME properties^[1].
SIK-IN-6 (0.001-100 μM; 4 days) induces cytotoxicity in MEF2C-high MOLM13 AML cells with a GI₅₀ of 1500 nM^[1].
SIK-IN-6 (0.001-100 μM; 3 days) selectively induces cytotoxicity in MEF2C-high MV4-11 AML cells with a GI₅₀ of 1200 nM, while sparing MEF2C-low U-937 AML cells and noncancerous HEK-293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MOLM13 (MEF2C-high AML) cells
Concentration:

0.001-100 μM
Incubation Time:

4 days
Result:

Induced cytotoxicity with a GI₅₀ of 1500 nM.

Cell Viability Assay^[1]

Cell Line:

MV4-11 (MEF2C-high AML), U-937 (MEF2C-low AML), and HEK-293 (noncancerous) cells
Concentration:

0.001-100 μM
Incubation Time:

3 days
Result:

Induced cytotoxicity in MV4-11 cells with a GI₅₀ of 1200 nM.
Showed no significant cytotoxicity in U-937 cells (GI₅₀ 29000 nM).
Showed no significant cytotoxicity in HEK-293 cells (GI₅₀ >30000 nM).

Chemical Information

Molecular Weight 478.49
Formel C₂₆H₂₄F₂N₄O₃
SMILES

COC1=CC(C2=CN=C3N2C=CC(C4=CC(C)=NC(C)=C4)=C3)=CC(OC)=C1C(N5CC(F)(C5)F)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Webb DT, et al. Structure–activity relationship studies resulting in the identification of potent and selective salt-inducible kinase inhibitors. ACS Med Chem Lett. 2016;7(7):726-731.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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SIK-IN-6

Alle Salt-inducible Kinase (SIK) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

SIK-IN-6 Related Classifications

HY-184954 Related Classifications