Teriflunomide impurity 3
Based on 1 Customer Validation
Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor with an IC50 of 30 µM. Teriflunomide impurity 3 is less active against COX-2 (IC50>100 µM).
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- Reinheit: 99.75%
- CAS. Nr.: 1011244-72-6
- Formel: C14H11F3N2O
- Molecular Weight:280.25
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
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COX-1 30 μM (IC50) |
Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide; compound 11q) is an amide-bond-reversed compound bearing trifluoromethyl and amino substituents showed potent COX-1-selective inhibitory activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1011244-72-6
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Appearance Solid
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Molecular Weight 280.25
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Formel C14H11F3N2O
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Color White to yellow
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SMILES
O=C(NC1=CC=C(C(F)(F)F)C=C1)C2=CC=C(N)C=C2
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Synonyms
4-Amino-N-(4-trifluoromethylphenyl)benzamide
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Lösungsmittel & Löslichkeit
DMSO : 250 mg/mL (892.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
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- Deutsch - DE (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5682 mL | 17.8412 mL | 35.6824 mL | 89.2061 mL |
| 5 mM | 0.7136 mL | 3.5682 mL | 7.1365 mL | 17.8412 mL | |
| 10 mM | 0.3568 mL | 1.7841 mL | 3.5682 mL | 8.9206 mL | |
| 15 mM | 0.2379 mL | 1.1894 mL | 2.3788 mL | 5.9471 mL | |
| 20 mM | 0.1784 mL | 0.8921 mL | 1.7841 mL | 4.4603 mL | |
| 25 mM | 0.1427 mL | 0.7136 mL | 1.4273 mL | 3.5682 mL | |
| 30 mM | 0.1189 mL | 0.5947 mL | 1.1894 mL | 2.9735 mL | |
| 40 mM | 0.0892 mL | 0.4460 mL | 0.8921 mL | 2.2302 mL | |
| 50 mM | 0.0714 mL | 0.3568 mL | 0.7136 mL | 1.7841 mL | |
| 60 mM | 0.0595 mL | 0.2974 mL | 0.5947 mL | 1.4868 mL | |
| 80 mM | 0.0446 mL | 0.2230 mL | 0.4460 mL | 1.1151 mL | |
| 100 mM | 0.0357 mL | 0.1784 mL | 0.3568 mL | 0.8921 mL |
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