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Art. -Nr.: HY-186258

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TMEM175 agonist 4

TMEM175 agonist 4 (Compound 276) is a TMEM175 agonist. TMEM175 agonist 4 can be used for the research of neurodegenerative diseases and lysosomal storage diseases.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₂H₂₂F₂N₄O₂
Molecular Weight:412.43

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

TMEM175 agonist 4 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

TMEM175 agonist 4 (Compound 276) is a TMEM175 agonist. TMEM175 agonist 4 can be used for the research of neurodegenerative diseases and lysosomal storage diseases^[1].

IC₅₀ & Target^[1]

TMEM175

138 nM (EC₅₀)

In Vitro

TMEM175 is a bifunctional channel protein located on the lysosomal membrane with permeability to both protons and potassium ions. It maintains lysosomal homeostasis and α-synuclein degradation, and its loss-of-function mutations significantly increase the risk of Parkinson's disease.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 412.43
Formel C₂₂H₂₂F₂N₄O₂
SMILES

FC(C1=C2CCCC1)=CN(C(C)C(NC3=CC=C(C4=C(F)C=NN4C)C=C3)=O)C2=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. RUDD,Michael T, et al. TMEM175 AGONISTS, COMPOSITIONS, AND METHODS OF USE. WO2026136191 25.06.2026.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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