Salbutamol hemisulfate
Based on 7 publication(s) in Google Scholar
Salbutamol (Albuterol) hemisulfate is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol hemisulfate promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol hemisulfate can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 51022-70-9
- Formula: C13H22NO5S0.5
- Molecular Weight:288.14
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Salbutamol hemisulfate
More- Adv Sci (Weinh). 2024 Sep 4:e2402393. [Abstract]
- J Hazard Mater Lett. 2025 Nov.
- Cell Rep. 2019 Dec 3;29(10):2929-2935.e4 [Abstract]
- Anal Chem. 2025 Jul 15;97(27):14220-14229. [Abstract]
- Eur J Med Chem. 2024 Dec 5:279:116842. [Abstract]
- Respir Res. 2022 Dec 28;23(1):380. [Abstract]
- Mol Biol Rep. 2026 Feb 26;53(1):434. [Abstract]
Customer Validation & Images
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In Vivo Efficacy Study
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IF
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WB
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RT-PCR
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Bio/Physico-chemical Assay
All Adrenergic Receptor Isoforms
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Biological Activity
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β adrenergic receptor |
Salbutamol (16 μM; 24 h) hemisulfate significantly induces EMT, migration and invasion by ERK (extracellular signal-regulated kinase) phosphorylation in gastric cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MGC803, SGC7901
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Concentration:16 μM
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Incubation Time:24 h
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Result:Increased β2-AR and ERK levels.Increased β2-AR and ERK levels. Upregulated mesenchymal markers, CDH2 (N-cadherin) and Snail expression, and decreased the expression of epithelial marker CDH1 (E-cadherin). Upregulated mesenchymal markers, CDH2 (N-cadherin) and Snail expression, and decreased the expression of epithelial marker CDH1 (E-cadherin).
Salbutamol (6 mg/kg; oral administration; 4 weeks) hemisulfate has a significant protective effect against Streptozotocin (HY-13753)-induced skeletal muscle atrophy in diabetic rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Streptozotocin induced diabetic rats[2]
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Dosage:6 mg/kg
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Administration:Oral administration (p.o.); 4 weeks
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Result:Enhanced muscle grip strength, coordination, and antioxidant levels.
Reduced proinflammatory markers and oxidative stress.
Reduced serum muscle biomarkers.
Increased testosterone, restored lipidemic levels, and improved muscle cellular architecture.
Chemical Information
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CAS No. 51022-70-9
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Appearance Solid
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Molecular Weight 288.14
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Formula C13H22NO5S0.5
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Color White to off-white
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SMILES
OC(C1=CC(CO)=C(O)C=C1)CNC(C)(C)C.O=S(O)(O)=O
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Synonyms
Albuterol hemisulfate; AH-3365 hemisulfate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (7)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Sleep Deprivation Triggers the Excessive Activation of Ovarian Primordial Follicles via β2 Adrenergic Receptor Signaling. [Abstract]2024 Sep 4:e2402393. PMID: 39229959
Salbutamol hemisulfate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393. [Abstract]
Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) significantly decreased both ovarian weight and the number of primordial follicles in C57BL/6J mice, along with a declining trend in the total follicle count.
Salbutamol hemisulfate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393. [Abstract]
Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) led to the upregulation of ADRB2 receptor expression in the granulosa cells of ovarian tissue in C57BL/6J mice.
Salbutamol hemisulfate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393. [Abstract]
Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) significantly increased the protein expression levels of KIT and KITL in the ovarian tissue in C57BL/6J mice.
Salbutamol hemisulfate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393. [Abstract]
Salbutamol (SAL) (100 µM; 24 h) considerably increased the mRNA expression level of KITL in the ovarian granulosa cell line KGN.
Salbutamol hemisulfate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393. [Abstract]
Salbutamol (SAL) (100 µM; 24 h) increased the cAMP concentration in KGN cells.
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Cell Rep
2019 Dec 3;29(10):2929-2935.e4 PMID: 31801060 -
Anal Chem
2025 Jul 15;97(27):14220-14229. PMID: 40601392 -
Eur J Med Chem
2024 Dec 5:279:116842. PMID: 39260319 -
Respir Res
Nebulization of risedronate alleviates airway obstruction and inflammation of chronic obstructive pulmonary diseases via suppressing prenylation-dependent RAS/ERK/NF-κB and RhoA/ROCK1/MLCP signaling. [Abstract]2022 Dec 28;23(1):380. PMID: 36575527 -
Mol Biol Rep
Cardiac drug potential: exploring individual and combined cardiac drugs to promote differentiation of adipose-derived stem cells into cardiomyocytes. [Abstract]2026 Feb 26;53(1):434. PMID: 41746444
Solvent & Solubility
H2O : 100 mg/mL (347.05 mM; Need ultrasonic)
DMSO : 2 mg/mL (6.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (347.05 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Lu Y, et al. Chronic stress model simulated by salbutamol promotes tumorigenesis of gastric cancer cells through β2-AR/ERK/EMT pathway. J Cancer. 2022 Jan 1;13(2):401-412. [Content Brief]
[2]. Hong YP, et al. Effects of Castanospermine on Inflammatory Response in a Rat Model of Experimental Severe Acute Pancreatitis. Arch Med Res. 2016 Aug;47(6):436-445. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.4705 mL | 17.3527 mL | 34.7053 mL | 86.7634 mL |
| 5 mM | 0.6941 mL | 3.4705 mL | 6.9411 mL | 17.3527 mL | |
| H2O | 10 mM | 0.3471 mL | 1.7353 mL | 3.4705 mL | 8.6763 mL |
| 15 mM | 0.2314 mL | 1.1568 mL | 2.3137 mL | 5.7842 mL | |
| 20 mM | 0.1735 mL | 0.8676 mL | 1.7353 mL | 4.3382 mL | |
| 25 mM | 0.1388 mL | 0.6941 mL | 1.3882 mL | 3.4705 mL | |
| 30 mM | 0.1157 mL | 0.5784 mL | 1.1568 mL | 2.8921 mL | |
| 40 mM | 0.0868 mL | 0.4338 mL | 0.8676 mL | 2.1691 mL | |
| 50 mM | 0.0694 mL | 0.3471 mL | 0.6941 mL | 1.7353 mL | |
| 60 mM | 0.0578 mL | 0.2892 mL | 0.5784 mL | 1.4461 mL | |
| 80 mM | 0.0434 mL | 0.2169 mL | 0.4338 mL | 1.0845 mL | |
| 100 mM | 0.0347 mL | 0.1735 mL | 0.3471 mL | 0.8676 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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