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Cat. No.: HY-184039

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Adosupine

Adosupine is a tricyclic compound that affects detrusor hyperreflexia via central nervous system sites. Adosupine can be used in studies related to detrusor hyperreflexia and urinary incontinence.

For research use only. We do not sell to patients.

CAS No.: 88124-26-9
Formula: C₁₇H₁₄N₂O₃
Molecular Weight:294.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Adosupine Chemical Structure

CAS No.: 88124-26-9

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Adosupine is a tricyclic compound that affects detrusor hyperreflexia via central nervous system sites. Adosupine can be used in studies related to detrusor hyperreflexia and urinary incontinence^[1]^[2].

In Vitro

Adosupine (500-1500 μg/mL) exhibits ideal linearity and high precision within this concentration range, with a CV < 0.1% for 1000 μg/mL Adosupine^[2].
Adosupine exists in only one crystalline form, and its amorphous form can be obtained by evaporating its dichloromethane solution at room temperature^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Adosupine (50 mg/kg; p.o.; single dose) distributes into rat plasma and brain, with peak concentrations detected around 100 minutes post-dose^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 88124-26-9
Molecular Weight 294.30
Formula C₁₇H₁₄N₂O₃
SMILES

O=C1C2=C(N(C)C(C3=C1C(NC(C)=O)=CC=C3)=O)C=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. D'Aranno V, et al. Determination of the tricyclic compound adosupine and its three metabolites in plasma and brain of rat using high-performance liquid chromatography. Journal of chromatography. 1992 Feb 14;574(2):319-25. [Content Brief]

[2]. Perico A, et al. Synthesis, characterization, and analytical studies of adosupine, a potential new drug for urinary incontinence. Journal of pharmaceutical sciences. 1994 Feb;83(2):137-42. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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