EIF4EBP2 - eukaryotic translation initiation factor 4E binding protein 2 Gene

Also Known as 4EBP2; PHASII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1979

About EIF4EBP2

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:70,404,145-70,428,618 (from NCBI)

This gene has 1 transcript (splice variant), 205 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 50.2), kidney (RPKM 34.8) and 25 other tissues.

Summary

This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, Insulin and Other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral Infection. [provided by RefSeq, Oct 2008]

EIF4EBP2 Products (1)

mRNA Protein Name
NM_004096.5 NP_004087.1 eukaryotic translation initiation factor 4E-binding protein 2

EIF4EBP2 Protein Structure

eIF_4EBP

eIF_4EBP: Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) (8 - 120)

  • 0
  • 100
  • 120 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 4E-binding protein 2

  • 4E-BP2

EIF4EBP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EIF4EBP2 Q13542 EIF4E Homo sapiens P06730
NMR
24207126
Intra
EIF4EBP2 Q13542 EIF4E Homo sapiens P06730
Y2H Prey Pooling
25416956
Intra
EIF4EBP2 Q13542 EIF4E Homo sapiens P06730
ITC
24207126
Intra
EIF4EBP2 Q13542 EIF4E Homo sapiens P06730
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF4EBP2 Proteins

Cat. No. Product Name Accession Purity
HY-P70416 EIF4EBP2 Protein, Human (His) Q13542 (M1-I120) ≥ 90%, as determined by reducing SDS-PAGE.

EIF4EBP2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81334 eIF4EBP2 Antibody (YA1079) WB Human, Mouse, Rat
HY-P81334A eIF4EBP2 Antibody (YA1079)(PBS only) WB Human, Mouse, Rat
HY-P85622 eIF4EBP2 Antibody (YA5314) WB Transfected

Related Diseases

Diseases Alias
Fragile X Syndrome

  • FXS

  • Martin-Bell Syndrome

  • Fraxa Syndrome

  • Marker X Syndrome

  • X-Linked Mental Retardation And Macroorchidism

  • Fragile X Mental Retardation Syndrome

  • Fra Syndrome

  • Mental Retardation, X-Linked, Associated With Marxq28

  • X-Linked Intellectual Disability And Macroorchidism

  • Frax Syndrome

  • Symptomatic Form Of Fragile X Syndrome In Female Carriers

  • Fragile-X Syndrome

  • Fraxe Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04278 EIF4EBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20664 Eif4ebp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27175 Eif4ebp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus EIF4EBP2 VGNC VGNC:28413
Canis familiaris EIF4EBP2 VGNC VGNC:40287
Mus musculus EIF4EBP2 MGD MGI:109198
Rattus norvegicus EIF4EBP2 RGD RGD:1310824
Macaca mulatta EIF4EBP2 VGNC VGNC:106043
Others EIF4EBP2 NCBI