GFRA3 - GDNF family receptor alpha 3 Gene

Also Known as GDNFR3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2676

About GFRA3

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,252,380-138,274,621 (from NCBI)

This gene has 2 transcripts (splice variants), 260 orthologues and 4 paralogues. Broad expression in testis (RPKM 2.5), colon (RPKM 2.3) and 18 other tissues.

Summary

The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF Receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, Artemin. [provided by RefSeq, Jul 2008]

GFRA3 Products (1)

mRNA Protein Name
NM_001496.4 NP_001487.2 GDNF family receptor alpha-3 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glial cell-derived neurotrophic factor receptor activity IDA
IDA: Inferred from direct assay
31535977 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16765900 GOA
Biological Process GO Annotation Evidence References Source
involved in glial cell-derived neurotrophic factor receptor signaling pathway IDA
IDA: Inferred from direct assay
31535977 GOA
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
9576965 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GFRA3 Protein Structure

GDNF

GDNF: GDNF/GAS1 domain (44 - 123)

GDNF

GDNF: GDNF/GAS1 domain (162 - 239)

GDNF

GDNF: GDNF/GAS1 domain (248 - 340)

  • 0
  • 100
  • 200
  • 300
  • 400 a.a.
Protein Preferred Names Protein Names

GDNF family receptor alpha-3

  • GDNF receptor alpha-3

Recombinant GFRA3 Proteins

Cat. No. Product Name Accession Purity
HY-P77372 GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His-Fc) O60609-1/NP_001487.2 (D32-W382) ≥ 80%, as determined by reducing SDS-PAGE.
HY-P77373 GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His) O60609-1/NP_001487.2 (D32-W382) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Postsurgical Hypothyroidism

  • Postoperative Hypothyroidism

  • Post-Surgical Hypothyroidism
Retinitis Pigmentosa 19

  • RP19

  • Retinitis Pigmentosa-19

  • Retinitis Pigmentosa, Type 19
Hirschsprung Disease 1

  • Hirschsprung Disease

  • Aganglionic Megacolon

  • Hscr

  • Hirschsprung'S Disease

  • Congenital Megacolon

  • Congenital Intestinal Aganglionosis

  • Colonic Aganglionosis

  • Hirschsprung Disease, Susceptibility To, 1

  • Hirschsprung Disease, Protection Against

  • HSCR1

  • Mgc

  • Pelvirectal Achalasia

  • Total Intestinal Aganglionosis

  • Megacolon, Aganglionic

  • Macrocolon

  • Hscr 1

  • Hirschsprung Disease Type 1

  • Hirschsprung Disease, Type 1

  • Congenital Dilatation Of Colon

  • Aganglionosis

  • Congenital Aganglionic Megacolon

  • Aganglionosis Of Colon

  • Bowel Aganglionosis

  • Colon Aganglionosis

  • Hirschsprung Megacolon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05388 GFRA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19200 Gfra3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25688 Gfra3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99748 Nadecnemab Inhibitor 95.00% Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GFRA3 VGNC VGNC:62531
Macaca mulatta GFRA3 VGNC VGNC:72919
Mus musculus GFRA3 MGD MGI:1201403
Bos taurus GFRA3 VGNC VGNC:29334
Canis familiaris GFRA3 VGNC VGNC:41191
Rattus norvegicus GFRA3 RGD RGD:620502
Others GFRA3 NCBI